PHAR 740 Week 2

Acyclovir (brand name)

Zovirax

Acyclovir (indication)

Genital herpes, shingles, varicella, cold sores

Acyclovir (contraindications/black box warnings)

Hypersensitivity to acyclovir or valacyclovir

Acyclovir (key counseling points)

Complete full course, hydrate adequately, start within 24h of lesions/rash, for prophylaxis reduces breakouts, improvement in 2-3d

Acyclovir (adverse effects >10%)

Malaise

Azithromycin (brand name)

Zithromax, Z-pak

Azithromycin (indication)

COPD, skin infection, sinusitis, pneumonia, STIs, strep throat

Azithromycin (contraindications/black box warnings)

Hypersensitivity to macrolides/ketolides, ergot alkaloids (contraindicated)

Azithromycin (key counseling points)

Complete full course, take with/without food (better tolerated with food), don't mix suspension with food, improvement in 2-3d

Azithromycin (adverse effects >10%)

Diarrhea, nausea, vomiting

Atorvastatin (brand name)

Lipitor

Atorvastatin (indication)

Hypercholesterolemia, ASCVD prevention, familial hypercholesterolemia

Atorvastatin (contraindications/black box warnings)

Hypersensitivity, breastfeeding, active liver disease, persistent LFT elevations

Atorvastatin (key counseling points)

Avoid excess alcohol/grapefruit, continue diet/exercise, report muscle pain/weakness

Atorvastatin (adverse effects >10%)

Diarrhea, headache, nasopharyngitis, myopathy

Esomeprazole (brand name)

Nexium

Esomeprazole (indication)

GERD, erosive esophagitis, H. pylori infection, prevention of NSAID ulcers, Zollinger-Ellison syndrome

Esomeprazole (contraindications/black box warnings)

Hypersensitivity to omeprazole/esomeprazole

Esomeprazole (key counseling points)

Take 1hr before meals, complete full regimen if for H. pylori, avoid multiple acid reducers, taper after long-term use

Esomeprazole (adverse effects >10%)

Headache

Cephalexin (brand name)

Keflex, Daxbia

Cephalexin (indication)

Skin infection, osteomyelitis, otitis media, respiratory tract infection, UTI, strep throat, impetigo, cellulitis

Cephalexin (contraindications/black box warnings)

Hypersensitivity to cephalosporins

Cephalexin (key counseling points)

Complete full course, shake/store suspension refrigerated, short expiration after reconstitution, avoid mixing with food, improvement in 2-3d

Cephalexin (adverse effects >10%)

Nausea

Clonidine (brand name)

Catapres, Kapvay

Clonidine (indication)

Hypertension, ADHD

Clonidine (contraindications/black box warnings)

Hypersensitivity, epidural use (boxed warning)

Clonidine (key counseling points)

Avoid alcohol/CNS depressants, don't stop abruptly (rebound HTN), ER tabs swallow whole, rotate patch site, caution driving

Clonidine (adverse effects >10%)

Nervousness, headache, somnolence, xerostomia

Famotidine (brand name)

Pepcid

Famotidine (indication)

Duodenal/gastric ulcer, GERD, indigestion/heartburn

Famotidine (contraindications/black box warnings)

Hypersensitivity to famotidine or other H2 antagonists

Famotidine (key counseling points)

Take at bedtime, may take with food/antacids, shake suspension well

Famotidine (adverse effects >10%)

Constipation, diarrhea, nausea, skin rash

Baclofen (brand name)

Lioresal, Ozobax

Baclofen (indication)

Spasticity

Baclofen (contraindications/black box warnings)

Hypersensitivity, avoid abrupt discontinuation (boxed warning)

Baclofen (key counseling points)

May cause sedation/dizziness, avoid alcohol/CNS depressants, caution with driving/machinery

Baclofen (adverse effects >10%)

Nausea, dizziness, somnolence, confusion

Cetirizine (brand name)

Zyrtec

Cetirizine (indication)

Allergic rhinitis, chronic urticaria

Cetirizine (contraindications/black box warnings)

Hypersensitivity to cetirizine or hydroxyzine

Cetirizine (key counseling points)

May cause sedation, avoid alertness-requiring activities until effects known

Cetirizine (adverse effects >10%)

Drowsiness

Cefuroxime (brand name)

Ceftin, Zinacef

Cefuroxime (indication)

COPD, sinusitis, otitis media, UTI, pharyngitis, gonorrhea, skin infection

Cefuroxime (contraindications/black box warnings)

Hypersensitivity to cephalosporins

Cefuroxime (key counseling points)

Complete full course, shake/store suspension refrigerated, expires in 10d, improvement in 2-3d

Cefuroxime (adverse effects >10%)

Diarrhea