Germ theory
Microorganisms called germs. Pasteur and koch proposed microorganism to be the cause of infectious diseases.
Infectious disease
disruption of normal body functions spread by direct or indirect contact
pathogens
microorganisms and viruses that cause disease
Non specific
Consists of the first and second lines of defense
First line of defense
Skin, tears, saliva, mucus, secretions contain lysozymes: which break up microorganism membranes.
Second line
Inflammatory response, swelling, redness, heat, pain and inflammation.
Mast cells
histamine cell for increased blood flow to the affected area
Fever
Body temperature is elevated to speed up immune response
Specific defense
Recognize self and non self
Antigens(protein)
pathogens have these on their outer surface. Help to identify the pathogen
Lymphocytes
white blood cell
Antibody
recognizes antigen because they have a matching shape
Helper T cell function
activates a b cell
B cell function
B cells lead to plasma cells and Memory B cells
Plasma cells
make lots of antibodies (unbound/free floating)
Memory B cell
excess antibodies are stored in the memory B cells to remember how to get rid of a certain virus
B cell+Helper T cell
equals Plasma cell and Memory B cell
Humoral Immunity
Pathogen enters the body(1st line of defense breached)
Inflammatory response
(HI starts)B cell antibody matches the pathogen’s antigen(ID)
Helper T cell activates production of memory B cells and plasma cells
Memory B cells remember and store antibodies, specific to the antigen used for a possible future attack by the same antigen(later)
Plasma cells are produced releasing antibodies to fight the pathogen(Now)
Vaccines
1.An inactive, weakened version of the pathogen is injected into the body.
2.Antibodies are made
3. Immune response is faster upon future exposure (secondary response)
Cell mediated Immunity
Pathogen enters the body, Inflammatory response(non specific defense)
1.Macrophage(phagocyte-WBC) engulf pathogen and display the antigens on its own surface
2.Helper T cells detect the macrophage and make more copies of Helper T cells
3a.Helper T cell makes memory T cells
3b.Helper T cell activates cytotoxic T cells(always being produced in the enzymes)
Immune system disorders
Sometimes the immune system overreacts to antigen.(Kawasaki, Aids, Lupus)
allergies
body’s inflammatory response to allergens(pet dander, pollen and food allergies)
Asthma
constriction of airways (hereditary and environmental causes)
Autoimmune disease
non recognition of self cells
Passive immunity
Natural: placenta, breast milk. Allows nutrients, oxygen and antibodies. Injection of externally produced antibodies. Temporary.
Active Immunity
Natural exposure: infection. Prevented by vaccines and making antibodies. Long lasting.
Capsid
protein coat surrounding a virus(Have DNA or RNA0
Virus Reproduction
A virus is nonliving.
Viruses can reproduce only by infecting living cells. A virus antigen attaches on host cell receptors.
Classifying Prokaryotes
Unicellular
No nucleus
DNA in cytoplasm
Bacteria or Archaea
Typical Bacterial Structure
Bacteria include a wide range of organisms; many phyla are needed to classify this group.
Structure and Function of Prokaryotes
vary in size, shape, and movement.No movementPropelled by flagella, Glide on secretions
Bacilli
Rod shaped
Cocci
spherical
Spirilla
spiral
Aids(HIV)
Helper T cell, which are needed for normal immune system function, are destroyed. Sexual contact; contact with contaminated blood or body fluids; can be passed to babies during delivery or during breastfeeding.
Tuberculosis
Fatigue, weight loss, fever, night sweats, chills, appetite loss, bloody sputum from lungs. Bacteria particles are inhaled.
What Are Fungi?
Heterotrophic eukaryotes
What are Protists?
Protists are eukaryotes; not members of the plant, animal, or fungi kingdoms.
Some protists are more like members of other kingdoms.
Antibiotics
medicine that fights bacterial infections (only)
How can bacteria change?
Bacteria can mutate very quickly to become resistant to the antibiotics which leads humans to make stronger antibodies. Bacteria have evolved.