* Alcohol - (behavior change, varying effects, can lead to frontal lobe damage if consumed in high doses it could damage, reasoning, hippocampus, forming memories and keeping memories)
* Sedatives (ex: barbiturates and benzodiazepines) - barbiturates are usually used for anesthesia for surgery, and benzodiazepines are used to induce calm and relaxation… ex: valium and Xanax
* Opioids aka Narcotics (morphine, heroin, fentanyl) - a class of drugs derived from opium (pain reliever) - made to mimic our own bodies pain-relieving endorphins, act on the brain as our own body would at varying degrees, they provide a level of bliss and relaxation (high potential for abuse)
* The opioid crisis started in the 90s (Pharmaceutical companies pushed for giving opioids to people experiencing high levels of pain) (it takes about 5-7 salt specs to overdose on fentanyl)