Drug metabolism and excretion

Outline phase 1 metabolism

Drug functional groups reduced, increases polarity.

Outline phase 2 metabolism

drug is conjugated to be more ionised and therefore more water soluble

give an example of a difference between P2 metabolism in dogs vs cats

Theobromine (chocolate)

dogs cannot excrete?

describe drug secretion

(polarity, protein binding)

describe the role of the liver and plasma proteins in drug distribution

plasma protein bind to drugs, lessening the free drug concentration, and can limit the ability of drugs to leave vessels.

liver metabolises drugs, lessening conc

describe entero-hepatic recycling.

bile from gall bladder enter SI

reabsorbed in SI into hepatic portal vein

made into bile again

looooooops