Activating/Deactivating directionals

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Last updated 11:34 PM on 9/10/26
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6 Terms

1
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Weak ortho-para activators

alkyl groups (methyl, ethyl, propyl, butyl, etc)

2
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Moderate meta deactivators

Ketones, esters (COOR), carboxylic acids (COOH), anything with carbonyl groups

3
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Strong meta deactivators

C☰️N, NO2, NR3 (tertiary amine), SO3H,

4
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Weak ortho-para deactivators

Halogens

5
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Moderate ortho-para activators

Lone pairs “distracted” with carbonyl group, -OCH3, -OR

<p>Lone pairs “distracted” with carbonyl group, -OCH3, -OR</p>
6
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Strong ortho-para activators

-O ion, -NH2, -NHR, -NR2, -OH (atom directly attached to ring has a lone pair)