prothrombotic alterations by endothelial cells (thrombosis)
- downregulate the expression of thrombomodulin - secrete Plasminogen activator inhibitors (PAI), which limit fibrinolysis
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Stasis and turbulence promote thrombosis by
- endothelial cell activation + procoagulant activity - platelets and leukocytes come into contact with endothelium - slows the washout of activated clotting factors
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Turbulence contributes to arterial and cardiac thrombosis by causing _____________ ____________, as well as by forming ___________ and local pockets of ________
endothelial injury, countercurrents, stasis
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Abnormalities of vessel wall in thrombosis causes
- atherosclerosis - inflammations
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Disorders of blood flow in thrombosis causes
slowed/stopped flow, turbulence
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Abnormalities of blood components in thrombosis causes