[PCOG-LEC-FIN-01-PT4] VITAMINS AND VITAMIN-CONTAINING DRUGS

THIS FLASHCARDS IS ABOUT [PCOG] VITAMINS AND VITAMIN-CONTAINING DRUGS - WATER-SOLUBLE VITAMINS

Pantothenic Acid

Vitamin B5 is also called as?

Vitamin B5 (Pantothenic Acid)

This vitamin is a component of the vitamin B complex that is sometimes known as the “chick antidermatitis factor”.

Chick Antidermatitis Factor

Vitamin B5 (Pantothenic Acid) is also known as?

Vitamin B5 (Pantothenic Acid)

This vitamin is naturally occurring compound that on hydrolysis yield B-alanine and pantoic acid.

1. B-alanine

2. Pantoic Acid

Vitamin B5 (Pantothenic Acid) yields (1)_____ and (2)__________ on hydrolysis.

1. Coenzyme A

2. Carbohydrates

3. Lipids

4. Proteins

The function of Vitamin B5 (Pantothenic Acid): precursor of (1)________, a cofactor that is essential for metabolism of (2)_____, (3)_____, and (4)_____.

Burning Foot Syndrome

What is the deficiency state of Vitamin B5 (Pantothenic Acid)?

• B1

• B6

• B12

What is the common combination of vitamin B complex?

Pyridoxine

Vitamin B6 is also called as?

Vitamin B6 (Pyridoxine)

This vitamin is a term that is applied to pyridoxol, pyridoxal, and pyridoxamine.

• Pyridoxol

• Pyridoxal

• Pyridoxamine

Vitamin B6 (Pyridoxine) is a term that is applied to (3)?

Hint: 3 PYRI

Microorganism

Vitamin B6 (Pyridoxine) is synthesized from ________ in large guts.

1. Protein synthesis

2. Fat metabolism

The function of Vitamin B6 (Pyridoxine): participates in an important coenzyme system, in (1)_____ synthesis and is involved in (2)_____ metabolism.

Pyridoxal 5-phosphate

What is the main active form of Vitamin B6 (Pyridoxine)?

• Meat

• Banana

• Whole Grains

• Nuts

• Potatoes

What are the (5) Dietary Sources of Vitamin B6 (Pyridoxine)?

Hint: MB-WNP

Supplemental Info

The deficiency states of Vitamin B6 (Pyridoxine) resembles niacin and riboflavin deficiencies.

• Confusion

• Irritability

• Convulsive seizures

• Skin lesions

• Glossitis

• Seborrheic dermatitis

• Hypochromic and Microcytic Anemia

What are the (8) Deficiency State of Vitamin B6 (Pyridoxine)?

Hint: CIC-SG-SHM

Biotin

Vitamin B7 is also called as?

Vitamin B7 (Biotin)

This vitamin occurs in so-called a- and B- forms, which differ in their side-chain structure.

Vitamin H

Vitamin B7 (Biotin) is also known as?

1. a-

2. B-

Vitamin B7 (Biotin) occurs in so-called (1)___ and (2)___ forms, which differ in their side-chain structure.

1. Imidazolidone

2. Tetrahydrothiophene rings

3. Valeric acid side chain

Vitamin B7 (Biotin) has a physiologically active substance that consists of fused (1)_____ and (2)__________ rings and (3)__________ side chain.

Carboxyl-carrying cofactor

The function of Vitamin B7 (Biotin): ________ cofactor in several carboxylase and decarboxylase enzyme systems.

• Alopecia

• Erythroderma desquamativa (Leiner’s Disease)

• Seborrheic dermatitis

What are the (3) Rare Examples of Deficiency State of Vitamin B7 (Biotin)?

Hint: AES

Leiner’s Disease

Erythroderma desquamativa is also known as?

• Folate

• Folic Acid

• Folacin

Vitamin B9 is also called as (3)?

P-aminobenzoic acid (PABA)

What is the precursor of Vitamin B9?

Vitamin B9

This vitamin refers to pteroylmonoglutamic acid, as distinct from the tri- and heptaglutamic acids is also found in this group of substances.

1. Pteroylmonoglutamic acid

2. Heptaglutamic acids

Vitamin B9 refers to (1)__________ acid, as distinct from the tri- and (2)__________ acids is also found in this group of substances.

Antianemia properties

The function of Vitamin B9: it has as ________ properties.

Tetrahydrofolic acid

What is the active form of Vitamin B9?

1. Folate coenzyme

2. 1-carbon units

The pharmacodynamic of Vitamin B9: function via a series of (1)______ coenzymes that are acceptors and donors of (2)_____ units in amino acid and nucleotide metabolism.

• Megaloblastic anemia

• Macrocytic anemia

• Glossitis

What are the (3) Deficiency State of Vitamin B9?

Hint: MMG

N5-Formyltetrahydrofolic acid (Folinic Acid)

What is the preparation of Vitamin B9 called?

Leucovorin

N5-Formyltetrahydrofolic acid (Folinic Acid) is marketed under what brand name?

N5-Formyltetrahydrofolic acid (Folinic Acid/Leucovorin)

This is a naturally occurring biochemical metabolite of folic acid that finds special use in anticancer drug regimen.

1. Folate antagonist

2. ‘Folic acid rescue’ antidote

N5-Formyltetrahydrofolic acid (Folinic Acid) is employed as (1)_____ antagonist and as ‘(2)____________’ antidote in chemotherapeutic regimens.

Cobalamin/Cyanocobalamin

Vitamin B12 is also called as?

Vitamin B12 (Cyanocobalamins)

This vitamin refers to a series of porphyrin-related corrinoid derivatives that function as extrinsic factors to prevent pernicious anemia.

1. Porphyrin-related corrinoid derivatives

2. Pernicious anemia

Vitamin B12 (Cyanocobalamins) refers to a series of (1)____________ derivatives that function as extrinsic factors to prevent (2)_______ anemia.

1. Cobalt

2. Corrin nucleus

3. Porphyrin nucleus of heme

Vitamin B12 (Cyanocobalamins) contains (1)_____ and (2)_____ nucleus, derived biosynthetically via pathway that is similar to that for the (3) Porphyrin _________________.

1. Cell reproduction

2. Growth

3. Hematopoiesis

4. Synthesis of myelin and nucleoprotein

The function of Vitamin B12 (Cyanocobalamins): essential to (1)____ reproduction, (2)____, (3)________, and synthesis of (4)_____ and ________.

Cyanocobalamins

What is the most stable form of cobalamins?

• Megaloblastic anemia

• Irreversible neurologic damage

What are the (2) Deficiency State of Vitamin B12 (Cyanocobalamins)?

Hypokalemia

What is the adverse effect of Vitamin B12 (Cyanocobalamins)?

Ascorbic Acid

Vitamin C is also called as?

1. Living cells

2. Enzymatic reactions

The function of Vitamin C (Ascorbic Acid): essential for the normal functioning of (1)_____ cells and is involved in many (2)_____ reactions.

1. Cartilage

2. Teeth

3. Bones

4. Wound healing

5. Iron from the intestine

Vitamin C (Ascorbic Acid) is required for the development of (1)___, (2)___, and (3)___, for (4)_____ healing and for the aiding the absorption of (5)_____ from the intestine.

• Rose hips

• Black currant

• Juice from citrus fruits

Vitamin C (Ascorbic Acid) can be prepared synthetically or by extraction from plant materials. Examples are (3)?

Hint: RBJ

Scurvy

What is the deficiency state of Vitamin C (Ascorbic Acid)?

Symptoms: Fatigue, Muscular pain and weakness, Stress, Skin lesions, Bleeding gums, Reduced resistance to infection, and Easy bruising

Sailors

Who is the most vulnerable from scurvy back then?

1. Deficiency conditions

2. Wound healing

3. Urinary acidifier

4. Methenamine

5. Deferoxamine

6. Antioxidant

Vitamin C (Ascorbic Acid) is used as drug & supplementation:

• Prevent or treat (1)_____ conditions

• Enhance (2)____ healing

• (3) Urinary _____ to enhance the effectiveness of (4)________

• Used with (5)________ in Iron toxicities to increase excretion of the iron

• (6)______ utilized in the food industry and in the formulation of some pharmaceutical preparation