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Most surgical site infections occur in the late postoperative phase, between days ____ after the procedure, but may be up to 90 days if an implant is involved.
5 and 30
3 types of surgical site infections
superficial incisional
deep incisional
organ / space
The initial management of surgical site infections includes ______
(+) fluctuance or drainage
wound exploration and debridement.
(indirect/direct) inguinal hernias pass into the scrotum
indirect
What disorders are associated with multiple endocrine neoplasia type 2?
Pheochromocytoma, hyperparathyroidism, amyloidosis, and medullary thyroid carcinoma.
initial screening test for pts with suspected ZES
fasting serum gastrin level and gastrin pH
Diagnosis is made if gastric pH is < 2 and the serum gastrin level is > 10 times the upper limit of normal (1,000 pg/mL).
ZES
gastric pH level in ZES
< 2
For patients with high suspicion for ZES but who do not meet the diagnostic criteria, a _____ may be helpful in aiding diagnosis
secretin stimulation test
72-year-old woman presents to the clinic with bilateral lower extremity edema for the past 3 months. The patient reports an aching pain in her legs that is worse with prolonged sitting or standing.
chronic venous insufficiency
lower extremity pain (often described as heaviness or aching) and edema
chronic venous insufficiency
Telangiectasia and reticular veins are common, mild, and early findings
chronic venous insufficiency
Symptomatic patients with suspected venous insufficiency should undergo further evaluation with _____ to identify the presence of superficial, perforator, and deep venous reflux
venous duplex ultrasonography
Patients may also have skin hyperpigmentation, which is due to hemosiderin staining and inflammation, and lipodermatosclerosis, which is a fibrosing panniculitis that presents with hyperpigmentation and induration.
chronic venous insufficiency
non-pitting edema think
lymphedema
pain exacerbated with walking and improved with rest
PAD
pain worse with prolonged standing / sitting still with feet in a dependent position
chronic venous insufficiency
leg swelling improves with walking
chronic venous insufficiency
Elevating the extremities improves the pain of ____
chronic venous insufficiency
Elevating the extremities exacerbates the pain in patients with severe ___
PAD
68-year-old woman presents to the clinic with pain in her legs for 4 months.
She feels the pain in her lower legs, the right side being more intense, after she walks three blocks in her neighborhood. She reports relief from the pain with rest. She reports no trauma or injuries to her feet. On physical examination, the dorsalis pedis pulse of the right foot is 1 and 2 on the left foot. A couple of nonhealing wounds are noted to the right lower extremity.
PAD
chronic venous insufficiency
no venous ulcers present
tx?
compression stockings
are compression stockings used for PAD
no
initial step in PAD management
prevent 2* cardiovascular events
- smoking cessation
- antiHTN therapy
- antilipid therapy
- antiplatelet therapy
- weight reduction
trial supervised exercise therapy
leg skin appearing shiny, dry, and hairless
PAD
Diagnosis of H. pylori infection is made by ____ or ____
H. pylori fecal antigen test
urea breath test
tissue samples from upper endoscopy ulcer are urease +
H pylori
Patients with _____ present with hearing loss, tinnitus, and disequilibrium. Additional symptoms include trigeminal and facial nerve dysfunction.
acoustic neuromas (vestibular schwannoma)
how to dx acoustic neuromas (vestibular schwannoma)
brain MRI with gadolinium contrast
an inner ear disorder that typically presents with episodic (recurrent episodes) of vertigo, fluctuating hearing loss, tinnitus, and aural fullness
ttacks often last for hours at a time and can be associated with nausea and vomiting. Following the acute attack, patients will feel excessively fatigued
meniere dz
The mainstay treatment for Ménière disease is _____
____ may be used in an acute attack
a low-sodium diet and diuretics
vestibular suppressants such as meclizine
What condition is associated with bilateral acoustic neuromas?
Neurofibromatosis type 2.
Patient presents with gradual hearing loss, tinnitus, balance disturbance
acoustic neuromas (vestibular schwannoma)
Most commonly caused by CN VIII (vestibulocochlear) tumor
acoustic neuromas (vestibular schwannoma)
Compromised blood supply of the hernia contents
strangulated hernia
Trapping of the hernia contents within the hernia sac
incarcerated hernia
what ABI indicates calcification / warrants referral to vascular specialist
> 1.4
what ABI is normal
1-1.4
what ABI is severe arterial dz
< 0.5
what ABI is arterial dz
0.9 or less
What medical conditions are most likely to cause falsely elevated ankle-brachial index measurements?
Diabetes and end-stage kidney disease.
MC gastric carcinoma
adenocarcinoma
If anal fissures are located laterally, search for ____
pathologic etiologies (e.g., Crohn disease)
What symptoms comprise the Reynolds pentad?
Fever, jaundice, abdominal pain, hypotension, and mental status changes.
Which vaccinations are recommended for patients who are undergoing splenectomy?
Haemophilus influenzae type b
Pneumococcal
Meningococcal
Other recommended immunizations not based on spleen status (e.g., zoster, seasonal influenza, SARS-CoV-2)
diverticulitis abx
cipro + metro
What infectious diseases should be screened for prior to initiating therapy with tumor necrosis factor-alpha inhibitors?
Hepatitis B and tuberculosis.
What group of medications should be avoided with known thoracic aortic aneurysms due to increased risk of dissection and rupture?
Fluoroquinolones
Many patients are asymptomatic or have minor symptoms.
Symptoms that may be present include dyspnea on exertion, fatigue, anginal chest pain, palpitations, presyncope, and syncope, particularly during or immediately following exertion
HOCM
Physical exam findings include bisferiens carotid pulse in severe disease, which is a double pulse noted during systole in the peripheral pulse.
A left ventricular lift may also be present.
A loud systolic murmur is present along the left sternal border that increases with Valsalva maneuver and upright posture and decreases with squatting
HOCM
True or false: continuing beta-blockers during pregnancy is recommended in patients with hypertrophic cardiomyopathy.
True
A 48-year-old man presents with abdominal pain. It is diffuse and developed suddenly about 20 minutes ago. He has a history of coronary artery disease and atrial fibrillation. On physical examination, the patient appears toxic, is crying out, and is writhing in pain. His temperature is 100.7°F, heart rate is 135 bpm, blood pressure is 84/52 mm Hg, respiratory rate is 24/minute, and oxygen saturation is 98% on room air. His abdomen appears distended but soft, there are hypoactive bowel sounds and no rebound tenderness. The patient displays abdominal guarding. Laboratory studies show a white blood cell count of 13.2 × 109/L and lactic acid level of 6 mg/dL.
what does he have
acute mesenteric ischemia
imaging for acute mesenteric ischemia
CTA
Patients will present classically with severe abdominal pain that is out of proportion to physical exam finding
acute mesenteric ischemia
What are the three major mesenteric vessels?
Celiac artery, superior mesenteric artery, and inferior mesenteric artery.
Colonoscopy is recommended for patients _____ after acute diverticulitis to assess the extent of a patient’s diverticular disease and exclude a concomitant colonic cancer. The only exception is patients who have had a colonoscopy performed within the past year.
6 to 8 weeks
what labs in DM pts preoperatively
serum glucose
A1C
EKG
serum creatinine
What is the goal intraoperative blood glucose level range?
Between 110 and 180 mg/dL
hyperparathyroidism:
bone pain
muscle twitching
perioral numbness
seizures
bone pain
muscle twitching
hypocalcemia
perioral numbness
hypocalcemia
seizures
severe hypocalcemia
“stones, bones, groans, and psychiatric overtones.”
hyperparathyroidism
MCC of hypercalcemia
hyperparathyroidism
high pth
high calcium
low phosphorus
hyperparathyroidism
shoulder / arm pain
horner syndrome (ipsilateral eye droop, pupillary constriction, posterior displacement of eye, absent sweating)
weakness and atrophy of hand muscles
pancoast syndrome
The chief finding is facial and upper extremity edema, but symptoms and signs also include dyspnea and neurologic manifestations
SVC syndrome
Superior sulcus tumor
pancoast tumor
What are some psychotropic agents that may induce galactorrhea?
Antipsychotics, monoamine oxidase inhibitors, neuroleptics, selective serotonin reuptake inhibitors, and tricyclic antidepressants
what type of ulcer feels worse with eating
gastric
diet for gastroparesis
low fat
low fiber
scintigraphy food retention test for gastroparesis
A positive test is defined as:
retention of > 10% of gastric contents after 4 hours
or
> 60% gastric retention after 2 hour
a useful prokinetic agent that can help improve gastric motility, but it is only recommended after dietary modification has been tried
metoclopramide
other prokinetics: domperidone, erythromycin
Which of the following is the correct mechanism of action of thioamides (methimazole, PTU)?
Interferes with the enzyme thyroid peroxidase, preventing the oxidation of iodine
mechanism: blocks thyroid hormone release
lithium
What adjunctive medication lowers serum T4 and T3 concentrations when given with methimazole?
cholestyramine
What is the first-line therapy for rickets?
ergocalciferol
MC location LBO
sigmoid colon
MCC LBO
colorectal cancer
Tx LBO
NGT, surgery
autoimmune condition affecting intrahepatic bile ducts
MC seen in women between age 40-60
characterized by a slow onset of increasing fatigue
Pruritus is also a hallmark of this disorder
Other findings: jaundice, esophageal varices, hepatosplenomegaly
Primary biliary cholangitis (PBC)
To confirm the diagnosis, antimitochondrial antibodies are tested.
Primary biliary cholangitis (PBC)
First-line treatment of primary biliary cholangitis (PBC)
ursodeoxycholic acid
Most commonly caused by an autoimmune T-cell-mediated attack on the intralobular bile ducts
Primary biliary cholangitis (PBC)
burn injury --> infection
pseudomonas aeruginosa
burn injury / pseudomonas abx
Ceftazidime plus tobramycin
grape-like odor
blue/green skin discoloration
pseudomonas
When a burn wound is infected with _____, it has been described visually as previously re-epithelialized areas "melting away."
MRSA
Patients with what chronic disease should avoid aminoglycosides?
Kidney disease
most often diagnosed between 30 and 40 years of age (although diagnosis can occur at any age)
It is more common in men and more frequently observed in those who do not smoke
Risk factors include irritable bowel disease (IBD), ulcerative colitis, Crohn disease, and other autoimmune disorders
Primary sclerosis cholangitis (PSC)
a progressive, autoimmune liver disease in which inflammation, fibrosis, and strictures of the biliary ducts of the liver lead to cholestasis and liver failure
Primary sclerosis cholangitis (PSC)
Lab results may show elevated alkaline phosphatase (a characteristic finding).
As an autoimmune condition, antinuclear antibodies and smooth muscle antibodies may be positive
Primary sclerosis cholangitis (PSC)
Many patients are asymptomatic, although some patients may report right upper quadrant abdominal pain, jaundice, fatigue, and pruritus.
In late-stage disease, patients may have jaundice, gastrointestinal bleeding, and ascites.
The physical exam may reveal hepatomegaly or splenomegaly.
Primary sclerosis cholangitis (PSC)
what imaging for Primary sclerosis cholangitis (PSC)
cholangiography
liver biopsy: onion skin fibrosis
tx of Primary sclerosis cholangitis (PSC)
no gold standard
immunosuppressants and prednisolone
ERCP with balloon dilation may be therapeutic
liver transplant
considered a premalignant condition and can progress to cholangiocarcinoma
Primary sclerosis cholangitis (PSC)
pts with Primary sclerosis cholangitis (PSC) should be monitored for what
cholangiocarcinoma
fat-soluble vitamin deficiencies
cholestatic pattern with ↑ alkaline phosphatase, +p-ANCA
Primary sclerosis cholangitis (PSC)
What is a complication after subarachnoid hemorrhage (SAH) that can lead to delayed cerebral ischemia?
vasospasm
What is the most frequent complication of acute cholecystitis?
Gangrenous cholecystitis