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Fear
Response to an immediate, real danger
Activates fight or flight
Serve adaptive functions, can become maladaptive
Panic attack: occurs when fear arises in absence of real danger
Anxiety
Diffuse apprehension about possible future threats
Cognitive & anticipatory
Serve adaptive functions, can become maladaptive
Maladaptive
Anxiety enhances learning & performance when mild
Prepares individuals to anticipate & manage future threats
Chronic or excessive anxiety becomes _____ & may lead to anxiety disorders
Social Anxiety Disorder (SAD)
Marked fear of social situations due to concern of negative evaluation (29%)
Social anxiety disorder
Core features of ______:
Fear of scrutiny or judgement
Avoidance of social situations
Distress in everyday interactions
Causes of ….
Cognitive bias
Negative interpretations of social cues
Memory recall biased toward negative evaluations
Biological factors
Behavioral inhibition as a temperament trait
Amygdala hyperactivity in response to negative facial expressions
Perceptions of uncontrollability
Childhood experiences of unpredictability
Leads to submissive & avoidant behaviors
Treatment of …
Cognitive-behavioral therapy (CBT)
Exposure to feared social situations
Cognitive restructuring to correct negative self-perceptions
Medication
SSRIs
Monoamine oxidase inhibitors
Panic disorder
Recurrent, unexpected panic attacks (4.7%)
Symptoms …
Rapid heart beat
Sweating
Shortness of breath
Fear of losing control/dying
Biological causes …
Genetic contributions
Moderate heritability
Overlap with phobias & separation anxiety
Neurobiology
Overactive fear network involving the amygdala & locus coeruleus
Decreased GABA activity, leading to heightened anxiety
Neurotransmitters
Serotonin → regulate mood & anxiety
Norepinephrine → linked to panic attacks
Treatment of …
Cognitive-behavioral therapy
Cognitive reconstruction to correct catastrophic thoughts
Exposure to feared bodily sensations
Medication
SSRIs
Benzodiazepines (short term, risk for dependence)
One, month
Diagnosis of panic disorder: At least ____ attack followed by a ____ to worry about future attacks or behavior change
Agoraphobia
Fear & avoidance of situations where escape may be difficult (80-90%)
Triggers:
Public transport
Open spaces
Crowded places
Fear of experiencing a panic attack in public
Generalized anxiety disorder (GAD)
Chronic, excessive worry about various aspects of life
Causes of …
Biological factors
Genetic predisposition
Neurotransmitter imbalance
Overactive corticotropin-releasing hormone system
Psychological factors
Low tolerance for uncertainty
Perceptions of uncontrollability & unpredictability
Childhood trauma may increase risk
Reinforcing properties of worry
Treatment of …
Cognitive-behavioral therapy
Focuses on identifying & reconstructing worry-related thoughts
Behavioral interventions → muscle relaxation & exposure therapy
Medication
SSRIs
Benzodiazepines
Buspirone
GAD
Criteria for _____ …
Occurs more days than not for at least 6 months
Difficult to control worry
At least 3 of the following:
Restless or feeling on edge
Being easily fatigued
Difficulty concentrating
Irritability
Muscle tension
Sleep disturbances
Body dysmorphic disorder (BDD)
Preoccupation with perceived physical defects not visible or minor to others; compulsive behaviors
Causes …
Genetic & neurobiological factors
Moderate heritability
Overactivity in orbitofrontal cortex & caudate nucleus
Cognitive factors
Biased attention towards appearance-related stimuli
Distorted perception of facial symmetry
Emotional abuse/neglect history increases risk
Treatment of …
Cognitive-behavioral therapy
Exposure and response prevention (reducing mirror checking, avoidance)
Challenging distorted beliefs about appearance
Medication
SSRIs (higher dose than OCD)
Compulsive behaviors
Mirror-checking, excessive grooming, reassurance seeking
Avoidance of social situations due to distress
Severe causes:
Social isolation
Depression
Suicidal ideation
Obsessive-compulsive disorder (OCD)
Presence of obsessions (persistent, distressing intrusive thoughts), compulsions (repetitive behaviors or mental acts aimed at reducing distress), or both
Causes of …
Neurobiological factors
Dysfunction in orbitofrontal cortex, anterior cingulate cortex, and caudate nucleus
Low serotonin levels
Cognitive-behavioral factors
Attempts to suppress obsessions paradoxically increase their frequency
Evolutionary perspective
Compulsions like checking and washing may be exaggerated survival behaviors
Treatment of …
Medications
SSRIs (e.g., fluoxetine, fluvoxamine, sertraline) are the first-line treatment
Antipsychotics may be added for severe cases
Behavioral & cognitive-behavioral treatments
Exposure and response prevention (ERP)
Repeated exposure to feared stimuli without performing compulsions
Anxiety naturally reduces over time (habituation)
50-70% symptom reduction, long-lasting effects
Cognitive therapy
Targets catastrophic beliefs about obsessions
May enhance ERP effectiveness
Thought-action fusion
Belief that having a thought is morally equivalent to acting on it or increases the likelihood of it happening
Example: A mother with intrusive thoughts about harming her infant believes thinking it makes it more likely to happen
Results in:
Inflated sense of responsibility
Increased compulsive behaviors to prevent harm
OCD
Diagnostic criteria for ____:
Obsessions and, if present, compulsions cause significant distress or impairment
Time-consuming (more than 1 hour per day)
Not attributable to substance use or another mental disorder.
Hoarding disorder
Persistent difficulty discarding possessions, regardless of value
Results in …
Extreme clutter
Fire hazard
Unsanitary conditions
Neurobiological distinctions …
Different brain activation patterns than OCD
Poorer response to standard OCD treatments
Trichotillomania
Recurrent pulling at hair resulting in hair loss
Mood disorders
Involve extreme alterations in emotion—ranging from deep depression to intense, unrealistic euphoria
[Normal mood states may occur between episodes, although sometimes mixed symptoms can be present within a single episode]
Unipolar depressive disorders
Only depressive episodes are experienced
Lifetime prevalence 17%
12-month prevalence 7%
Women twice as likely as men to experience major depression
Bipolar disorders
Both depressive and manic (or hypomanic) episodes occur; normal mood states may occur between episodes, although sometimes mixed symptoms can be present within a single episode
Lifetime prevalence 1%
No specific gender differences
Depressive episode
Markedly depressed mood or loss of interest in once pleasurable activities for at least 2 weeks
Additional symptoms:
Changes in sleep and appetite
Feelings of worthlessness or guilt
Difficulty concentrating
Recurrent thoughts of death or suicidal ideation
Most common form of mood disorder
Manic episode
Abnormally and persistently elevated, euphoric, or expansive mood lasting at least 1 week (or any duration if hospitalization is needed)
Accompanied by three (or four if mood is only irritable) additional symptoms such as:
Inflated self-esteem or grandiosity
Decreased need for sleep
More talkative or pressured speech
Flight of ideas or racing thoughts
Distractibility
Increase in goal-directed activity or psychomotor agitation
Excessive involvement in high-risk activities
Hypomanic episode
Similar symptoms to mania, but less severe, lasting at least 4 days, with no marked impairment or need for hospitalization
Major depressive disorder (MDD)
Presence of a major depressive episode without any history of mania or hypomanic episodes
Key symptoms (at least 5 during a 2-week period) → symptoms must represent a change from previous functioning & cause significant distress or impairment:
Depressed mood most of the day
Markedly diminished interest or pleasure
Significant weight change or appetite disturbance
Sleep disturbances (insomnia or hypersomnia)
Psychomotor agitation or retardation
Fatigue or loss of energy
Feelings of worthlessness or excessive guilt
Diminished ability to think or concentrate
Recurrent thoughts of death or suicidal ideation
Melancholic, psychotic
Specifiers for MDD:
_____ features: early morning awakening, depression worse in the morning, psychomotor changes, loss of appetite/weight, excessive guilt
______ features: presence of delusions or hallucinations (usually mood-congruent
Delusions
Faulty fixed beliefs that contradict reality and have no truth
Hallucinations
Alterations in sensory perceptions without any external stimuli
Atypical features (of MDD)
Mood reactivity (mood brightens in response to positive events) plus two or more symptoms (e.g., weight gain, hypersomnia, leaden paralysis, sensitivity to rejection)
Catatonic features (of MDD)
Motoric immobility, including mutism and rigidity
Seasonal pattern (of MDD)
Recurrent depressive episodes occurring at the same time each year with full remission in other seasons
Persistent depressive disorder (PDD)
Depressed mood most of the day, on most days, for at least 2 years (1 year for children/adolescents)
Additional symptoms (at least two of the following)
Poor appetite/overeating
Insomnia/hypersomnia
Low energy
Low self-esteem
Poor concentration
Feelings of hopelessness
Key characteristic: intermittent periods of normal mood (lasting a few days to a few weeks, but never more than 2 months)
Double depression
Co-occurrence of persistent depressive disorder and intermittent major depressive episodes
Premenstrual dysphoric disorder
Symptoms appear in the final week before menses and improve soon after onset; key symptoms include affective lability, irritability/anger, depressed mood, or marked anxiety
Post-partum blues
Common in new mothers (and occasionally fathers), with symptoms like mood lability, crying, sadness, and irritability occurring in up to 50-70% within 10 days of childbirth and typically subsiding on their own
Hypoothalamic-pituitary-adrenal axis
Regulates cortisol release in response to stress
Elevated cortisol is observed in 20-40% of outpatients and 60-80% of hospitalized patients with depression
In about 45% of patients with serious depression, dexamethasone fails to suppress cortisol levels (the “dexamethasone nonsuppressor” phenomenon)
Prolonged cortisol elevations can lead to memory impairments, cognitive difficulties, and cell death in the hippocampus
Circadian rhythms
Regulate sleep & appetite
Abnormalities in these rhythms are commonly observed in depression
Seasonal affective disorder (SAD)
Linked to the total quantity of available light; most patients become depressed in the fall/winter and normalize in spring/summer
Light therapy may help reestablish normal biological rhythms in affected individuals
Sleep disturbances
______ _____ in depression
Normal sleep involves five stages (Stages 1-4 of non-REM and REM sleep)
Depressed patients frequently experience:
Difficulty falling asleep and maintaining sleep
Early morning awakening
A shortened latency to the first REM period (often 15-20 minutes sooner than normal)
Increased amounts of REM sleep in early cycles and reduced deep sleep
Such sleep changes are particularly pronounced in patients with melancholic features
Severe stressful events
E.g., loss of a loved one, major economic or health crises often precipitate a major depressive episode
Distinction between independent life events (e.g., natural disasters) and dependent life events (those partly generated by the person’s behavior).
Research indicates dependent life events may play a stronger role in triggering depression
Chronic stress
Ongoing for several months (e.g., poverty, marital discord), is associated with increased risk for the onset, maintenance, and recurrence of depression
Cognitive, biological
Psychological factors:
Stressful life events, personality traits (e.g., neuroticism), and negative cognitive styles all contribute to depression
_______ vulnerabilities (such as dysfunctional beliefs) may be activated by stressful events, triggering depressive symptoms
These psychological factors may also be mediated by underlying ______ changes (e.g., hormonal imbalances)
Freud and Abraham
Psychodynamic theory
“Mourning and Melancholia” (1917) noted similarities between depression and the symptoms of mourning
Proposed that depression involves the regression to an earlier developmental stage and the introjection of the lost object, leading to anger turned inward
Emphasis on both real losses and symbolic losses (e.g., failure in school or relationships) as triggers for depression
Aaron Beck
Cognitive theory
Argued that negative automatic thoughts often precede mood symptoms
Central to his model are dysfunctional beliefs or depressogenic schemas
The model highlights the “negative cognitive triad”:
Negative views about the self (“I’m worthless”)
Negative views about the world (“No one loves me”)
Negative views about the future (“It’s hopeless because things will always be this way”)
Cognitive biases (e.g., all-or-none thinking, selective abstraction, arbitrary inference) serve to maintain these negative thoughts
Learned helplessness model
Cognitive theory
Originated from animal studies showing that uncontrollable shocks lead to passivity and depressive symptoms
In humans, exposure to uncontrollable negative events may lead to a sense of helplessness that parallels these findings
The reformulated helplessness theory emphasizes that the attributions people make about negative events (internal, stable, global) determine their vulnerability to depression
Relationships, social
Interpersonal effects
Lack of close, supportive _____ increases vulnerability to depression
_____ isolation and deficits in interpersonal skills are risk factors
Criticism
Interpersonal effects
Studies show that ______ (e.g., maternal criticism) elicits different neural responses in recovered depressed individuals
Less activation in the prefrontal cortex
Heightened amygdala response
Parental, marital
Interpersonal effects
_____ depression raises risk for children
_____ distress can precipitate relapse in depression
Interpersonal cascade
Depressive behaviors can evoke negative reactions from others (e.g., rejection, hostility)
Persisting reassurance seeking
Effect of depression on others that may lead to strained relationships and further isolation
Marital and family contexts
Unsupportive or critical environments contribute to worse outcomes and relapse
Bipolar spectrum
Includes bipolar I, bipolar II, & cyclothymic Disorder
Bipolar I disorder
Characterized by full-blown manic episodes (often with depression)
Presence of full-blown mania; depressive episodes may be present even if subthreshold
Bipolar II disorder
Involves hypomanic episodes (less severe) and major depressive episodes
Presence of hypomania (milder, no hospitalization required) plus major depressive episodes
Cyclothymic disorder
Chronic, fluctuating mood disturbances (hypomanic and depressive symptoms over ≥2 years)
High heritability, family risk, shared genetics, polygenic
Genetic Factors in Bipolar Disorders
____ __________: twin studies show ~60% concordance for monozygotic twins vs. ~12% for dizygotic twins
_____ ______: first-degree relatives have a markedly increased risk
_____ ______: some genetic polymorphisms overlap with schizophrenia and unipolar depression
_____ nature: multiple genes contribute to liability for bipolar disorder
Monoamine hypotheses
Neurochemical & hormonal influences in bipolar disorders
Imbalances in norepinephrine, serotonin, and dopamine
Increased norepinephrine activity during mania; low serotonin in both phases
Hormonal dysregulation
Neurochemical & hormonal influences in bipolar disorders
HPA axis abnormalities (e.g., elevated cortisol in depression)
Thyroid function: abnormalities can affect mood; thyroid hormone may enhance antidepressant efficacy but also precipitate mania
Lithium therapy
Widely used for both depressive and manic episodes
Effective in reducing recurrence (especially in bipolar disorder)
Considerations:
Side effects - lethargy, weight gain, cognitive slowing, possible kidney issues
Alternative anticonvulsants (e.g., carbamazepine, divalproex) are used when lithium is not tolerated
Women, men, low, increases
Epidemiology of Suicide
Global impact:
Suicide is the 15th leading cause of death worldwide (≈1.4% of deaths)
Gender differences:
_____ are more likely to attempt suicide
_____ are about four times more likely to die by suicide due to use of more lethal methods
Age trends:
____ in childhood
____ from adolescence through young adulthood, with a middle-age peak
Pharmacological interventions:
Antidepressants may reduce suicidal ideation in adults, although concerns remain
Lithium shows strong anti-suicide effects in long-term management
Key warning signs
Nearly 90-95% of suicide victims have a history of at least one psychiatric disorder
Risk increases dramatically with comorbidity
_____ ______ (immediate action needed):
Threats to self-harm or suicidal statements
Seeking access to lethal means (pills, weapons)
Talking or writing about death or suicide
Additional concerns → hopelessness, agitation, withdrawal, increased substance use, and dramatic mood changes
Somatoform
Excessive thoughts, feelings, & behaviors about a bodily sensation
Disproportionate & persistent thoughts about the seriousness of symptom(s)
Excessive time & energy devoted to symptom(s)
Most tentative spectrum
Emotional dysfunction superspectrum
Difficult to derive due to less existing evidence
Somatoform
Assessment symptoms of … : MMPI or MSPQ
There seems to be a fullness in my head
I have numbness in my skin
I have a lump in my throat often
I do not notice my ears ringing (reversed)
Desire to pass water
Mouth becoming dry
Butterflies in stomach
Muscles twitching or jumping
Pain
Physical suffering
Somatoform with pain
Disproportionate & persistent thoughts about the seriousness of pain symptoms
Disproportionately excessive time & energy devoted to pain symptoms
Ex. Patient w/ fibromyalgia whose symptoms aren’t responding to/managed by typical intervention
Somatic symptom disorder
One or more x symptoms that are distressing or result in significant disruption of daily life
Excessive thoughts, feelings, or behaviors related to the x symptoms or associated health concerns as manifested by at least one of the following:
Disproportionate & persistent thoughts about the seriousness of one’s symptoms
Persistently high level of anxiety about health or symptoms
Excessive time & energy devoted to these symptoms or health concerns
Illness anxiety disorder
Preoccupation with having or acquiring a serious illness
Somatic symptoms are not present or, if present, only mild in intensity - if another medical condition is present or there is a high risk for developing a medical condition, the preoccupation excessive or disproportionate
High level of anxiety about health, & individual easily alarmed about personal health status
Individual performs excessive health-related behaviors or exhibits maladaptive avoidance
Illness preoccupation present for at least 6 months, but specific illness that is feared may change over that period of time
Illness-related preoccupation not better explained by another mental disorder
Care-seeking type
Medical care, including physician visits or undergoing tests and procedures is frequently used
Care-avoidant type
Medical care is rarely used
Functional neurological symptom disorder (conversion disorder)
A type of somatic disorder that is sometimes applied to patients who present neurological symptoms, such as numbness, blindness, paralysis, or fits, which are not consistent with a well-established organic cause, cause significant distress, and can be traced back to a psychological trigger
Functional neurological symptom disorder
______ ________ _______ ________ begins with some stressor, trauma, or psychological distress
Common symptoms include:
Blindness
Partial or total paralysis
Inability to speak
Deafness
Numbness
Difficulty swallowing
Incontinence
Balance problems
Seizures
Tremors
Difficulty walking
Factitious disorder
A condition in which a person, without a malingering motive, acts as if they have an illness by deliberately producing, feigning, or exaggerating symptoms, purely to attain (for themselves or for another) a patient's role; people with a factitious disorder may produce symptoms by contaminating urine samples, taking hallucinogens, injecting fecal material to produce sickness, and similar behavior
Factitious disorder imposed on another (also called Munchausen syndrome by proxy)
A condition in which a person deliberately produces, feigns, or exaggerates the symptoms of someone in their care
Dissociative
Characteristics of _______ disorders
Individuals becoming split off, or dissociated, from their core sense of self
Memory & identity become disturbed; disturbances have a psychological rather than physical cause
Depersonalization
Characteristic of dissociative disorders:
A feeling of detachment or estrangement from one’s self; feeling as if you are an onlooker of your own body
Qualitative study, conducted by by Ciaunica et al., 2023, reveals lived experienced of individuals struggling with depersonalization, and found three core themes:
Individuals with high levels of depersonalization reported:
Detachment from the world and one’s self – “I just feel like I’m watching myself over a distance and I don’t know who I am”
Embodiment, denoting unusual or changing experiences of the body – “whenever I feel intimidated, I tend to lose control of my body and can’t move properly”
Identity changes, a lack of congruence between one’s felt self and one’s words and action — “My thinking self and my speaking self feel different”
Derealization
Characteristic of dissociative disorders:
An alteration in the perception of one’s surroundings so that a sense of reality of the external world is lost; the world you are experiencing doesn’t feel real
The sense that one is in a “fog”
A see-through wall or veil is separating you from your surroundings
The world appears lifeless, muted, or fake
Objects or people look “wrong” – blurry, unnaturally sharp, too big, or too small
Sounds are distorted, too loud, or too soft
Time seems to speed up or stand still
Dissociative amnesia
Characteristic of dissociative disorders:
When dissociation causes memory loss
How memory works:
Encoding: the receival and interpretation of information
The act of getting info into our memory from either automatic and effortful processing
Storage: maintaining information over time
The retention of encoded information
Retrieval: the ability to access information when you need it
The act of getting information out of storage and into awareness through recall and recognition
Retrograde
When dissociative amnesia affects finding old memories
Anterograde
When dissociative amnesia blocks the formation or storage of new memories
Identity confusion
Characteristic of dissociative disorders:
Thoughts & feelings of uncertainty & conflict a person has related to their identity
“I have a feeling that I am made up of two or more people”
“It happens that I have the feeling that my mind is split up”
“At times it seems as if someone else inside of me decides what I do”
“It happens that I have the feeling that I am somebody else”
Identity alteration
Characteristic of dissociative disorders:
Manifestations of alters (or alternative identities) containing & expressing different opinions, perceptions, & senses of self
Individuals may notice a shift in their sense of how old they are, their gender identity, their preferences, skills, and memories
Even vocal pitch, body language, and physical reactivity to stress can change
Anorexia nervosa
Not simply a “lack of appetite” but a relentless pursuit of thinness leading to a significantly low body weight
DSM-5 criteria:
A - restriction of energy intake resulting in significantly low body weight
B - intense fear of gaining weight or becoming fat
C - disturbance in body weight/shape perception
Subtypes:
Restricting type - extreme limitations of food intake
Binge-eating/purging type - binging/purging behaviors
Bulimia nervosa
Characterized by recurrent binge eating followed by inappropriate compensatory behaviors
DSM-5 criteria highlights:
Recurrent episodes of binge eating (eating an unusually large amount of food in a short time with a loss of control)
Inappropriate compensatory behaviors (self-induced vomiting, misuse of laxatives, fasting, or excessive exercise)
Occurs at least once a week over 3 months
Clinical notes:
Typically, individuals are within a normal weight range or slightly overweight
Often accompanied by feelings of shame and guilt
Anorexia nervosa
Weight: Markedly low
Atypical anorexia: extreme weight loss, but bmi remains in the “normal” range (could be due to starting at a higher weight)
Behavior: Restrictive intake (or binge/purge in one subtype)
Body Image: Distorted perception; intense fear of weight gain
Bulimia nervosa
Weight: Normal or slightly overweight; no pronounced weight loss
Behavior: Binge eating with compensatory behaviors
Body Image: Overconcern with weight; feelings of shame
Binge-eating disorder
Weight: Often overweight or obese; not a requirement
Behavior: Binge eating without compensatory measures
Body Image: Concerns present, though less rigid dietary restraint compared to other disorders
Risk factors and demographics
Age of onset
Most eating disorders begin in adolescence
Binge-eating disorder often develops between ages 30-50
Gender differences
Historically seen as predominantly affecting females; current ratio is about 3:1 (female:male)
Men’s body dissatisfaction may focus on muscularity
High-risk groups
Individuals in professions emphasizing thinness (e.g., models, ballet dancers)
Athletes in sports with weight restrictions
Sociocultural pressures and media influence play significant roles
Anorexia nervosa
Medical complications:
Heart arrhythmias and risk of cardiac arrest
Electrolyte imbalances leading to kidney damage
Osteoporosis due to low bone density
Other signs: dry skin, brittle hair, lanugo (fine hair growth)
Bulimia nervosa
Medical complications:
Dental erosion and mouth ulcers from repeated vomiting
Swollen salivary glands
Electrolyte disturbances impacting heart and muscle function
Biological
________ factors
Genetic predisposition
Family and twin studies indicate high heritability for anorexia and bulimia nervosa
Recent GWAS found a genetic locus on chromosome 12 linked to anorexia nervosa and metabolic factors
Brain structure & neurotransmitter imbalances
Hypothalamus role - lateral hypothalamus stimulation promotes appetite
Serotonin - abnormalities (such as altered 5-HIAA levels) suggest disrupted serotonergic function
Set points & reward sensitivity
The body’s “set point” resists significant weight changes
Differences in reward processing (e.g., response to food cues) may predispose to binge eating or restrictive behaviors
Sociocultural
________ influences
Media & cultural ideals
Exposure to Western media (TV, magazines) is linked to body dissatisfaction
Studies (e.g., in Fiji) show that media can shift local attitudes toward thinness
Icons like Twiggy and Kate Moss have influenced the “thin ideal”
Internalization of the thin ideal
Believing that thinness equals beauty and success increases risk
Social comparisons and peer evaluation reinforce these beliefs
Family influences
Families of patients often exhibit rigid attitudes, high expectations, and focus on dieting
Parental preoccupation with appearance may contribute to the development of eating disorders
Individual, perfectionism
_______ variables
Personality traits
________: an enduring trait linked to rigid dieting and excessive self-criticism; more pronounced in women; men with eating disorders tend to be less perfectionist
Body dissatisfaction
A powerful predictor of eating disorder onset
Distorted self-perceptions lead to chronic dieting and negative self-evaluation
Negative emotionality & dieting behaviors
Dieting is common and can trigger or worsen disordered eating
Negative moods and depression are predictive of binge eating and dietary restriction