steroid hormones, prostaglandins, leukotrienes & lipoxins
Lipids are precursors for
rich source of energy & storage for excess calories
integral part of cell membrane
protection & insulation
General function of lipids
esterified
Fatty acids occur in ________ form (as building blocks for lipids), and free fatty acid form
glycerol, fatty acids
Triglycerides (triacylglycerols)
consists of 1 molecule of ______ esterified with 3 ________ molecules
liver
Triglycerides (triacylglycerols) present in dietary fat; synthesised in the _____ & adipose tissue
unsaturated
Cholesterol is _______ steroid alcohol; amphipathic lipid (both hydrophilic and hydrophobic)
bile acids, source of energy fuel
Cholesterol is the precursor of steroid hormones & _________; does not serve as a ___________
genetic abnormalities
environmental/lifestyle imbalances
secondary to other diseases
3 causes of dyslipidemias:
total cholesterol
HDL
LDL
triglycerides
4 different laboratory analyses for dyslipidemias:
Arteriosclerosis, Hypercholesterolemia, Hypertriglyceridemia
3 different lipid disorders
lipids, artery
Arteriosclerosis is the deposition of ______ (esterified cholesterol) in _____ walls
LDL
_____ → initiate & promote plaque formation in arteries
plaques, blood
Arteriosclerosis results in fatty streaks → _______ (smooth muscle cells, extracellular lipid, calcification & fibrous tissue) → partial or complete occulsion of ______ flow
genetic
Hypercholesterolemia and Hypertriglyceridemia
associated with ______ abnormalities
monosaccharide
disaccharide
oligosaccharide
polysaccharide
4 Classification of carbohydrates:
-(e.g., glucose, fructose, galactose) -(e.g., lactose, maltose, sucrose) -(e.g., oligofructose, maltotriose) -(e.g., amylose, glycogen)
glycogen
Glucose is primarily stored as ______ in liver & muscle
hyperglycemia, insulin
Diabetes Mellitus is a metabolic disorder characterised by chronic _______ arise from defects in the secretion, or action of ______, or both
pancreatic islet B-cell, ketoacidosis
type 1 diabetes mellitus
___________ destruction
tendency to ________
insulin, secretory
type 2 diabetes mellitus
______ resistance
insulin _______ defect
glucose, metabolic
gestational diabetes mellitus
______ intolerance
________ & hormonal changes during pregnancy
glucose
Prediabetes
higher than normal blood ______ level, but insufficiently high to be considered as diabetes
reversible
Prediabetes is _____
type 1, insulin/medication
Hypoglycaemia is common among
particularly in ______ diabetic patients
type 2 diabetic patients who are on _______
red blood cells white blood cells haemoglobin haematocrit platelets mean corpuscular volume (MCV)
Complete blood count measures and/or count:
polycythemia respiratory distress high altitude
increased level of RBCs may indicate:
iron anemia vitamin B12, vitamin B6 and/or folic acid anaemia haemorrhage liver & renal dysfunction
decreased level of RBCs may be a sign of:
inflammation, infection
elevated white blood cells count may indicate _________ or ________
autoimmune, bone marrow, cancers
low cell count of WBCs may indicate _______ diseases, b_________ disorders or ______
dehydration, emphysema, asthma, polycythemia
increased level of Hb may indicate:
iron deficiency anaemia, microscopic internal bleeding, digestive inflammation
decreased level of Hb may indicate:
packed
Hematocrit also known as _____ cell volume
atherosclerosis, rheumatoid/inflammatory arthiritis, certain cancers
increased level of platelets:
idiopathic thrombocytopenia, blood loss
decreased level of platelets:
red blood cell
Means Corpuscular Volume (MCV) is the volume in cubic microns occupied by an average single _______ basically size of ______
vitamin B12/folic acid, dehydration
↑ level (macrocytic RBCs): ________ anaemia, d_______
iron
↓ level (microcytic RBCs): _____ anaemia, microscopic internal bleeding