lectin pathway

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12 Terms

1
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activated MASP-2 associated with MBL or ficolin

cleaves C4 to C4a and C4b

2
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C4b

binds to microbial surface

3
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C4b binds to C2

__________, which is then c leaved by MASP-2 to C2a

4
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C4b2a

active C3 convertase of lectin pathway

5
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C3a and C3b

C4b2a cleaves C3 into _______________

6
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C3b

binds to microbial surface covalently

7
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MBL monomers

form trimeric clusters of carbohydrate recognition domains

8
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mannose and fucose residues

MBL binds with high avidity to

9
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different domain

ficolins are similiar in structure to MBL, but have a

10
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oligosaccharides

ficolins bind to

11
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MASP 1/2/3

are associated serine proteases that initiate the complement cascade

12
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lectin pathway

recognies differences in carbohydrate side chains on glycoproteins