Human Physio Immune System

B cells, plasma cells

Soluble proteins secreted by activated _____ and p______ in response to an antigen.

exocytosis

Indigestible and residual material is removed by_____.

pseudopods

Phagocyte forms ________ that eventually engulf the particle.

lysosomal enzymes

Microbe in fused vesicle is killed and digested by l_____ e______ within the phagolysosome, leaving a residual body.

Antibodies

________ pass from mother to baby via placenta or milk (no memory cells produced)

Adaptive immune system

________ is antigen specific, systemic, and has memory.

granzymes, apoptosis

Release ________ and activates Fas to induce ______.

Phagocytic vesicle

________ is fused with a lysosome.

Antibodies

________ become surface receptors marking the members of each clone.

fluid leak out of capillaries onto tissue

lymph

Humoral

(antibody) mediated (B cell) immunity

Helper T cells

regulate other immune cells

Cytotoxic T cells

attack & destroy virus infected cells (phagocytosis or chemical toxins)

plasma cells

secrete antibodies

5 classes of antibodies

IgD, IgM, IgG, IgA, and, IgE

on all nucleated human cells

MHC class I is found on:

cytotoxic t cells

MHC class I is recognise by:

macrophages, B lymphocytes, and dendritic cells

MHC class II is found on:

helper T cells

MHC class II is recognised by:

perforins

Cytotoxic T cells release pore forming _____

plasma, memory

Helper T cells bind to inactivated B cells to promote differentiation into ________ cells and ______ B cells

Helper T cells

secrete cytokines that activate other immune cells

Effector B cells

synthesies and secretes antibodies

antibodies

_______ are capable of binding specifically with antigen

attract immune cells and chemical mediators to the site

produce a physical barrier to retard the spread of infections

promote tissue repair once the infection is under control

Three important roles of inflammation:

specific, immediate, granulocytes, macrophages

Innate immunity

specific/non specific, slow/immediate response

guided by g_______ & m_______

Lymph nodes

filter lymph fluid before it has opportunity to enter back into blood vessels