Narrow Therpuetic Index
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13 Terms
narrow theraputic index drugs
defined as those drugs for which small differences in dose or blood concentration may lead to dose-and blood concentration-, serious theraputic failures or adverse reactions.
NTI Drugs drug dose response relationship
Steep drug dose-response relationship within the usual dose range or narrow span between effective drug concentrations and concentrations associated with serious toxicity.
NTI drugs drug monitoring
subject to therapeutic drug monitoring based on pharmacokinetic (PK) or pharmacodynamic (PD) measures to ensure safe and effective use of the drug.
Warfarin is considered an
NTI drug
Levothyroxine is considered a
NTI drug
Carbamazepine is considered an
NTI drug
Lithium carbonate is considered an
NTI drug
Digoxin is considered an
NTI drug
Phenytoin is considered an
NTI drug
Theophylline is considered an
NTI drug
NTI means: small dose change =
big problem
NTI means: easy to go from effective to
toxic
What type of monitoring do NTI drugs require
close monitoring with labs and blood levels being done routinely
