SLE amnd RA

associated with HLA-DR3

Kidney is the most common visceral involved

SLE

Strongly associated with HLA DR2

RA

What is the disease associated of this Pattern and autoantibody respectively

Paripheral or homogenous

Anti ds dna

Sle

What is the disease associated of this Pattern and autoantibody respectively

Homogenous

Anti histone

Anti dnp

Drug induced sle

What is the disease associated of this Pattern and autoantibody respectively

Coarse speckle

Anti sm

Diagnostic for SLE

What is the disease associated of this Pattern and autoantibody respectively

Coarse speckled

Anti-RNP

Sle and mixed connective tissue disease

What is the disease associated of this Pattern and autoantibody respectively

Finely speckled

Anti SSA and Anti SSB

SLE and sjogrens

What is the disease associated of this Pattern and autoantibody respectively

Prominent staining of nucleoli

Anti nucleolar

SLE, systemic sclerosis

What is the disease associated of this Pattern and autoantibody respectively

Atypical speckled

Anti-scl-70

Systemic sclerosis, scleroderma

What is the disease associated of this Pattern and autoantibody respectively

Fine cytoplasmic speckling

Anti-jo-1

Polymyositis

What is the disease associated of this Pattern and autoantibody respectively

Discrete speckled

Anti centromere

CREST

Pattern of fluoresence

Uniform staining of the entire nucleus

Homogenous/ diffuse

Pattern of fluoresence

Diffuse staining is throughout nucleus, but greater staining intensity around outer circle surrounding nucleus

Rim/ outline

Pattern of fluoresence

Discrete, fluorescent coarse/ fine specks throughout nucleus

Speckled

Prominent staining of nucleoli within the nucleus

Nucleolar

Pattern of fluoresence

Numerous discrete speckles are seen in the nucleus

Centromere