Foundations in Pharmacology - Antibodies

Flashcards covering key terms related to antibodies and their function in immunology.

Polyclonal Antibodies

Antibodies that are collected from sera of immunized animals and can recognize multiple antigenic sites of an injected antigen.

Monoclonal Antibodies

Identical antibodies produced in large quantities by an immortalized hybridoma cell line, recognizing only one antigenic site.

Hybridoma

A cell that is formed by the fusion of a specific B cell with a myeloma (cancer) cell, resulting in a cell that can produce monoclonal antibodies.

Immunoassay

A laboratory method used to detect or quantify the presence of substances, often using antibodies.

Chimeric mAb

Monoclonal antibodies that have both mouse and human components to reduce immunogenicity.

Humanized mAb

Monoclonal antibodies that have been modified to reduce the immune response when introducing antibodies from a mouse to a human.

Immunotoxins

Therapeutic molecules composed of monoclonal antibodies linked with a toxin to target specific cells.

Radioimmunotherapy

A therapeutic approach that combines radiation therapy with immunotherapy, using monoclonal antibodies conjugated with radioactive materials.