BPH

Benign Prostatic Hyperplasia

BPH

_____ is the most benign neoplasm in men, it’s the enlargement of the prostate gland which obstructs the urethra decreasing outflow of urine…

BPH

_____ symptoms of this include increased urinary frequency, increased urgency, excessive night urination, decreased force of urine stream and sensation of incomplete bladder emptying…

Urethra

BPH makes prostate gland enlarge around the _______…

5-alpha-reductase inhibitor and Alpha 1-adrenergic blocker

BPH symptoms can be relieved early in course of disease, two classes include…

Dutasteride (Avodart)

5 alpha reductive inhibitor drug is…

5-alpha-reductase inhibitor

______ MOA of this inhibits the conversion of testosterone to 5 a-dihydrotestosterone (DHT)…

DHT

______ is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland…

Dizziness and sexual dysfunction

Adverse effects of 5-alpha-reductase inhibitor…

Doxazosin (cardura), Alfuzosin (Xatral), Finasteride (proscar), Silodsin (Rapaflo), Tamsulosin (Flomax), Terazosin (Hytrin)

Alpha 1 adrenergic blockers include…

Alpha 1 adrenergic blockers

________ MOA improve urine flow by blocking alpha1-receptor-mediated increases in smooth muscle tone in the prostate, urethra and bladder neck (blocks the muscle that would constrict)…

Alpha 1 adrenergic blockers

________ Adverse effects if this include orthostatic hypotension, dizziness and sexual dysfunction…

Overactive bladder

Lower urinary tract symptoms (Luts) can be broadly described as relating to storage dysfunction or voiding dysfunction (trouble storing urine)…

29% and 5%

In Canada ___% of older females and ___% of older males report luts…

Urinary incontinence

________ is the complaint of involuntary leakage of urine…

Anticholinergics

Treatment of overactive bladder is _____…

Trospium (trosec), Tolterodine (Detrol), Solifenacin (Vesicare), Oxybutynin (Ditropan), Festoterodine (Toviaz), Darifenacin (Enablex)

Anticholinergics include…

Anticholinergics

_______ MOA is inhibiting acetylcholine-induced urinary bladder contractions…

Anticholinergics

________ Adverse effects include dry mouth, constipation, tachycardia, dry eyes (slows and drys)…