Chapter 5 part 1 (lectin pathway)
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14 Terms
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lectins
receptor proteins that recognize particular carbohydrate componenets on microbial cells
part of innate immune system (no antibodies)
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Mannose-binding lectin (MBL) binds to arrays of __
mannose residues on surface of microbial cells
acts as PRR
consitutively expressed by liver (part of collectins)
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microbes recognized by MBL
N-acetylglucosamine, D-glucose, and L-fucose polymers
salmonella, listeria, neisseria bacteria
cryptococcus neoformans and candida albicans fungi
HIV-1 and respiratory syncytial virus (RSV)
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other lectin pathway initiators
collectin-10 & 11
Ficolin 1, 2, and 3
all have a common “stalk”
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MBl is associated with MBL-ASP (associated serine proteases)
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Note 
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