Main treatments of Thyroid disorders - PBSci 7
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14 Terms
Thionamides (Methimazole, Propylthiouracil)
Inhibit thyroid peroxidase (TPO) to reduce iodination and coupling of MIT/DIT, decreasing T3/T4 synthesis
Radioactive iodine (I-131)
Selectively taken up by the thyroid where beta-emission destroys thyroid tissue
Surgery (thyroidectomy)
Physical removal of the thyroid gland to reduce hormone production
Beta-blockers (e.g., propranolol)
Block adrenergic symptoms like tachycardia and tremors
Iodide (Lugol's solution, KI)
High doses temporarily inhibit thyroid hormone release via the Wolff-Chalkoff effect
Levothyroxine (T4)
Synthetic T4 converted peripherally to active T3 to restore normal thyroid hormone levels
Liothyronine (T3)
Direct replacement with the active hormone
Hypothyroidism
Levothyroxine (T4)
Hypothyroidism
Liothyronine (T3)
Hyperthyroidism
Thionamides (Methimazole, Propylthiouracil)
Hyperthyroidism
Radioactive iodine (I-131)
Hyperthyroidism
Surgery (thyroidectomy)
Hyperthyroidism
Beta-blockers (e.g., propranolol)
Hyperthyroidism
Iodide (Lugol's solution, KI)
Note 
Flashcards (21)