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Topic 13: Innate Defense System
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Biology
BY 271
UAB
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207 Terms
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Prostaglandins
________= found in every tissue, hormone- like effect, lipid derived.
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Chemotaxis
________- inflammatory chemicals attract neutrophils to the injury site.
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Acute inflammation
________ is the immediate response of body to injury or cell death.
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Inflammation
________ is its hallmark and most important mechanism (cause of swelling, heat, redness)
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Physical activity
________ is needed to increase metabolic rate, heat production= This accomplished by shivering thermogenesis.
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complement proteins
All ________ are in the inactive state until activation when the host is challenged by an invading microbe.
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NK
________ cells: the absence of MHC class I molecules, specific types of antibodies, and.
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Soluble proteins
________ or glycoproteins that are released by one cell population that act as intercellular mediators or signaling molecules.
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Macrophages
________ and dendritic cells, become part of innate immune system and will respond to all antigens.
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Phagocytosis
________ can be greatly increased by opsonization.
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Skin bacteria
________ have a high salt toleration and dryness (mannitol salt agar !)
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Hydrogen cyanide
________: Used in chemical weapons.
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Salivation washes
________ microbes to stomach (pH 3- 5)
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PAMPs
________ are unique to microbes, not present in host.
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UTI
Bacteria can go up through urinary tract and cause ________, if not treated the bacteria can travel upwards.
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maturation
After ________ and activation are called plasma cells and produce antibodies.
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asthma allergic reactions
Play a role in ________ along with mast cells.
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Vinyl chloride
________: Used to make pipes.
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Tobacco
________ smoke contains a deadly mix of more than 7, 000chemicals.
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Chemokines
________- signaling proteins /cytokines.
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Toluene
________: Found in paint thinners.
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"probiotic-up to 500 species", "prebiotic"
up to ¾ immune system reside in your gut
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Immunity
Ability to ward off disease
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Innate immunity
Defenses against any pathogen
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Adaptive immunity
Immunity, resistance to a specific pathogen
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Second line of defense
antimicrobial proteins, phagocytes, and other cells
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Specialized lymphocytes
T and B cells (T cells are HIVs target; B cells give antibodies)
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Surface Barriers
Skin, mucous membranes, and their secretions make up the first line of defense
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Largest organ (20 sqft), 10+/
pounds
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Cellulitis
inflammation due to infection
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Warts
viral infection cause excess skin growth
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Herpes
HSV-1&HSV-2, periodic blisters around lips or genitals
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Tinea
skin mycosis
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Shingles
varicella zoster virus (linear DNA, lipid enveloped, herpes group)
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Lysozyme in saliva and tears
function
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*Antagonisms
competitive exclusion of normal microbiota (our bacteria)
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Langerhans cell
NOT islet of Langerhans in pancreas
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produces superoxide radicals
toxic
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80% lung cancer
due to smoking, 13% survive 5+ years
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Formaldehyde
Used to embalm dead bodies
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Polonium 210
Radioactive and very toxic
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Vinyl chloride
Used to make pipes
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Lead
Once used in paint
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Cadmium
Used to make batteries
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Hydrogen cyanide
Used in chemical weapons
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Butane
Used in lighter fluid
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Toluene
Found in paint thinners
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microaerophilic
likes less oxygen (strept throat test)
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Gastritis, linked to duodenal and stomach cancer
stress was to blame before the discovery
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1st infection
antibody test
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2nd and after
Urea or stool test
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Picture
blood has plasma and cells (red blood cells, platelets, and white blood cells); centrifuge separates layers
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Blood Plasma
approx. 55%
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Platelets donation
not from mama
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pregnant
may have antibody from baby
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Plasma donation
no tuberculosis, malaria, sickle cell anemia, cancer etc
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white blood cells (WBCs)
major role in the innate and specific responses
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Hematopoesis
hematopoetic stem cell differentiation process (all blood components)
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Dendritic Cells
Antigen-presenting cells (APC)
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60% of WBC
majority
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highly phagocytic
1st to go to site
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idopathic
dont know what it is, may be genetic
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need a signal (i.e antigen presenting cell
dendritic cell)
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Cytotoxic T-cells
the specific antigens presented by their MHC class I molecule
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NK cells
the absence of MHC class I molecules, specific types of antibodies, and
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Secondary lymphoid tissue includes
lymph nodes, tonsils, adenoids, Peyers patches (intestine), spleen
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*lectin
carbohydrate binding proteins
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*PPI
Alzheimers, CJD, Cancer
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Neutrophils
after digesting microbial fragments
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cardinal signs
PRISH
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Pain
release of chemicals such as histamine
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chemokines
signaling proteins/cytokines
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Margination
neutrophils cling to the walls of capillaries in the injured area
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Chemotaxis
inflammatory chemicals attract neutrophils to the injury site
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Example from your lab
Staphylococcus aureus, S. epidermidis, S. pyogenes (Gram+, β-hemolysis, catalase-), Escherichia coli, Pseudomonas aeruginosa
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composed of > 30 serum proteins
mainly produced in liver (pro-proteins)
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Feeling awful/miserable
treating the symptom, not the cause
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What generally composes the immune system?
wide variety of cells, tissues, and organs
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What is the function of the immune system?
recognizes foreign substances or microbes and acts to neutralize or destroy them
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What is prebiotic and probiotic?
probiotics line the intestine and prebiotic reside in the gut (stomach acid difference) and have a heavy impact on mental health, etc.
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What can compromise the immune system?
stress, health problems, unhealthy food and lifestyle
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What is immunity?
ability of host to resist a particular disease or infection; ability to ward off disease
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What is immunology?
science concerned with immune responses
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What is susceptibility?
lack of resistance to a disease
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What is innate immunity?
defenses against any pathogen; "nonspecific immunity"
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What is adaptive immunity?
immunity, resistance to a specific pathogen
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What are characteristics of innate (nonspecific) defense system?
responds quickly, offers resistance to any microbe or foreign substance, lacks immunological memory
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The first and second line of defense is part of the ___.
innate (nonspecific) defense system
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What is part of the first line of defense?
intact skin, mucous membranes and their secretions, and normal microbiota
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What is part of the third line of defense?
natural killer cells and phagyocytic WBC, inflammation and fever, antimicrobial substances
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What is the function of the second line of defense?
inhibit spread of invaders throughout the body, phagocytosis and inflammation key mechanisms
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What is antagonism?
normal bacteria, that is on skin, keeps the body clean from new microbes and will "antagonize" them
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What line of defense is antagonism present?
first line of defense
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What line of defense is pathocytosis and inflammation present?
second line of defense
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Adapative immunity (specific) has the ___ line of defense.
3rd
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What is the third line of defense?
specialized lymphocytes (T and B cells) and antibodies
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What cell is HIV's "target"?
T cells
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What cell makes antibodies?
B cells
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What are the two ways to get antibodies?
receieed by getting sick and producing B cells or getting vaccine with B cells
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What is adaptive (specific) defense system?
aka acquired or induced immunity; has immunology memory, responds to a very particular foreign substance
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