Top 100 Drugs - Including Common AEs

Indacaterol - glycopyrrolate brand

Ultibro

Indacaterol - glycopyrrolate class

LABA/LAMA

Indacaterol - glycopyrrolate AEs

Resp: cough, sore throat or mouth, runny/stuffy nose

CNS: dizzy, headache, tingling, shakiness, nervousness

GI: dry mouth, diarrhea, abdominal pain (possible Sx of gastroenteritis)

Acetylsalicylic acid brands

• Aspirin

• Asaphen

• Entrophen

• Novasen ECT

• Anacin

Acetylsalicylic acid AEs

GI: n/v/d, dyspepsia, bleeding/ulcers

CNS: tinnitus (at large doses)

Atenolol AEs

Resp: bronchospasm

CV: hypotension, worsening HF, bradycardia, heart block

CNS: fatigue, depression

sexual dysfunction in males

Diltiazem brands

• Cardizem LA

• Cardizem CD

• Tiazac

Diltiazem AEs

CV: edema, hypotension, heart block

CNS: headache

GI: constipation

Amlodipine AEs

CV: edema, postural dizziness

CNS: headache

GI: associated with gingival hyperplasia

Atorvastatin class

HMG-CoA Reductase Inhibitor

Atorvastain AEs

Skeletal: MSK pain, rhabdo (rare)

GI: liver function abnormalities

Neuro: headache

Domperidone AEs

CNS: headache

GI: dry mouth, abdominal cramping

Endocrine: galactorrhea

Use of domperidone

• Labelled: GI motility disorders, gastroparesis

• Unlabelled: GERD, chemo-induced n/v, improve lactation in nursing mothers

Ezetimibe AEs

• fatigue

• diarrhea

Estradiol brands

• Climara

• Vagifem 10

• Estring

• Estradot

Estradiol AEs

CV: increased BP

GI: n/v, abdominal discomfort

CNS: dizzy, nervousness

Gliclazide AEs

Metabolic: hypoglycemia

CV: edema

Derm: rash

GI: abdominal pain, constipation, n/v (usually dose-dependent for all GI)

Clarithromycin brand

Biaxin

Clarithromycin indications

• Upper/lower respiratory tract infection

• skin/soft tissue infection

• mycobacterium avium complex

Clarithromycin AEs

GI: taste disturbance, n/v/d

CNS: headache

Ciprofloxacin brands

• Cipro

• Cipro XL

• Ciloxan

Ciprofloxacin indications

• Respiratory tract infection

• UTI

• prostatitis

• skin/soft tissue infection

• bone/joint infection

• infectious diarrhea

• gonorrhea

Ciprofloxacin AEs

GI: n/d

CNS: dizzy, nervousness, insomnia

may cause photosensitivity

reports of tendon rupture - specifically achilles tendon

Ethinyl estradiol / various progesterones brand examples

• Marvelon

• Yaz

• Min-Ovral

• many others

Hydromorphone brands

• Dilaudid (HP, HP-Plus, XP)

• Jurnista

Hydromorphone AEs

CNS: dizzy, drowsy, somnolence, headache GI: constipation, n/v

Derm: flushing, sweating, itching

MSK: myoclonus seen at higher doses

Diclofenac / Misoprostol brand

Arthrotec

Diclofenac / Misoprostol class

NSAID / prostaglandin

Diclofenac / Misoprostol AEs

GI: abdominal pain, n/d, dyspepsia

Cyclobenzaprine unlabelled use

Fibromyalgia

Cyclobenzaprine AEs

CNS: drowsy, fatigue, dizzy

GI: dry mouth, urinary retention, increase IOP (intra-occular pressure)

Conjugated estrogens brands

• Premarin

• CES

Conjugated estrogens indications

• menopausal symptoms

• atrophic vaginitis

• osteoporosis prevention

Conjugated estrogens AEs

CV: increased BP

GI: abdominal pain

CNS: dizzy, nervousness

Azithromycin indications

• Upper/lower respiratory infections

• STD (chlamydia, gonorrhea)

• uncomplicated skin/soft tissue infection

Cephalexin indications

• uncomplicated skin/soft tissue infection

• URI

• acute cystitis

Escitalopram indications

• depression

• anxiety

• OCD

Escitalopram AEs

CNS: headache, somnolence, insomnia

GI: n/d, dry mouth

GU: decreased libido, anorgasmia, impotence

Canagliflozin AEs

• Hyperkalemia

• genitourinary infection

• constipation

• nausea

• thirst

• hypoglycemia (more common when used with sulfonylurea or insulin)

Esomeprazole AEs

CNS: headache

GI: n/v/d, flatulence, dry mouth

Citalopram AEs

CNS: insomnia, somnolence

GI: n/d, dry mouth

CV: postural hypotension, tachycardia

GU: sexual dysfunction, decreased libido

Fluticasone oral inhalation AEs

CNS: headache, dizzy

Resp: URI, pharyngitis, cough, hoarseness/throat irritation, thrush

Donepezil AEs

CNS: insomnia

GI: n/d (dose-related), anorexia

GU: urinary frequency, incontinence

bradycardia, syncope

Insulin glargine brands

• Lantus

• Toujeo

• Basaglar

Acetaminophen brands

• Tylenol

• Tempra

• Atasol

Acetaminophen AEs

Derm: pruritis

GI: constipation, n/v

CNS: headache, insomnia

Digoxin brands

• Lanoxin

• Toloxin

Digoxin AEs

CNS: dizzy, confusion

GI: n/v/d, anorexia

Ocular: blurred vision/yellow halo with toxicity

CV: AV block, bradycardia

Digoxin class

Cardiac glycoside

Clopidogrel class

Thienopyradine antiplatelet

Clopidogrel AEs

Hematologic: bleeding, bruising, epistaxis

Derm: rash

Aripiprazole indications

• schizophrenia

• bipolar disorder 1

• depression (adjunctive tx)

• Tourette’s disorder

Aripiprazole AEs

CNS: headache, extrapyramidal, drowsy, akathisia, fatigue, sedation, agitation, insomnia, anxiety

endocrine: weight gain, increased TG and LDL, less HDL, higher glucose

GI: n/v, constipation

Neuromuscular: tremor

Amoxicillin indications

• Upper/lower respiratory infection

• UTI

• H. pylori

• Lyme disease

Allopurinol AEs

Skin rash (including SJS) - usually maculopapular (more common with renal disorders)

GI: diarrhea, abdominal pain, n/v

Gabapentin class

Anticonvulsant

Gabapentin indications

• partial seizures

• pain associated with postherpetic neuralgia

Gabapentin AEs

CNS: dizzy, somnolence, fatigue

CV: pedal edema

GI: n/v/d, Neuromuscular: tremor

Ocular: nystagmus; weight gain

Lansoprazole brand

Prevacid

Bupropion brands

• Wellbutrin (SR, XL)

• Zyban

Bupropion class

Selective dopamine and norepinephrine re-uptake inhibitor

Bupropion indications

• depression

• seasonal affective disorder (SAD)

• smoking cessation

Bupropion AEs

Cardiac: tachycardia

CNS: headache, insomnia, dizzy

GI: dry mouth, constipation, nausea, weight loss

ENT: tinnitus

Ocular: blurred vision

Resp: nasopharyngitis

Celecoxib indications

• rheumatoid arthritis

• osteoarthritis

• acute pain

• ankylosing spondylitis

Celecoxib AEs

CV: peripheral edema

CNS: dizzy, insomnia

GI: abdominal pain, n/v/d, dyspepsia

Duloxetine indications

• depression

• GAD

• diabetic peripheral neuropathy

• fibromyalgia

• chronic low back pain

Duloxetine AEs

CNS: somnolence, dizzy, tremor

GI: nausea, dry mouth, anorexia, constipation

GU: ED

Furosemide AEs

Metabolic: hypokalemia, hypomagnesemia, hyperuricemia, photosensitivity

GI: anorexia

Bisoprolol brand

Monocor

Dabigatran AEs

Bruising, bleeding, abdominal pain, n/v/d, heartburn, upset stomach, difficulty swallowing, hives, pruritis, rash

Divalproex brand

Epival

Divalproex indications

• Epilepsy

• bipolar disorder

• migraine prophylaxis

Divalproex AEs

CNS: headache, somnolence, dizzy, insomnia, ocular problems, tremor (dose-related)

Derm: alopecia

GI: weight gain, n/v/d

Heme: thrombocytopenia (dose-related)

PCOS, pancreatitis

Clonazepam brand

Rivotril

Clonazepam indications

Seizures

Clonazepam AEs

CNS: drowsy, fatigue, somnolence, dizzy; associated with anterograde amnesia

Amitriptyline brand

Elavil

Amitriptyline indications

• Depression

• Off label: pain, migraine prophylaxis, neuropathy

Amitriptyline AEs

Anti-Chol: dry mouth, urinary retention, constipation

CNS: drowsiness, fatigue

CV: ortho hypo, tachycardia

weight gain

Amitriptyline class

Tricyclic antidepressant

Hydrochlorothiazide brand

Urozide

Hydrochlorothiazide AEs

CV: hypotension, orthostasis

Derm: phototoxicity, rash (including SJS)

Metabolic: hypokalemia, hypomagnesemia, hyperuricemia

Tamsulosin class

Alpha-1 adrenergic blocking agent

Tamsulosin AEs

CV: orthostasis

CNS: headache, dizzy

Resp: rhinitis

GU: abnormal ejaculation

Trazodone brand

Desyrel

Trazodone AEs

CNS: sedation, headache, drowsy, fatigue

GI: dry mouth, nausea

Ocular: blurred vision

Associated with rare occurrence of priapism with 1/3 of cases required surgical intervention

Zopiclone brand

• Rhovane

• Imovane

Zopiclone class

Sedative/hypnotic

Zopiclone AEs

CNS: sedation, amnesia, depression, confusion, dizzy

Sertraline indications

• Depression

• Panic disorder

• OCD

• PTSD

• SAD

Sertraline AEs

CNS: insomnia, somnolence

GI: n/d, dry mouth

CV: postural hypotension, tachycardia

GU: sexual dysfunction, decreased libido

Spironolactone indications

• HF

• primary aldosteronism

• hypokalemia

• cirrhosis

Temazepam brand

Restoril

Temazepam indications

Insomnia

Temazepam AEs

CNS: drowsiness, fatigue, somnolence, dizziness, hangover; Associated with anterograde amnesia

Venlafaxine indications

• Depression

• GAD

• Panic disorder

• Social anxiety disorder

Venlafaxine AEs

CNS: headache, somnolence, dizzy, insomnia, anxiety

GI: nausea, dry mouth, anorexia, constipation

GU: abnormal ejaculation

CV: hypertension (dose-related), palpitations

Sildenafil class

PDE-5 inhibitor

Sildenafil indications

• ED

• pulmonary HTN

Sildenafil AEs

CNS: headache

Ocular: small % of pts get visual effects (impairment of colour discrimination, increased perception to light, blurred vision, eye pain, ocular redness)