Final Exam (Cocaine)

What contributes to psychostimulant effects of cocaine?

Dopamine reuptake inhibition

How does intranasally administered cocaine limit its own absorption?

Cocaine is a potent vasoconstrictor, when intranasally administered, it reduces blood flow to the nasal mucosa limiting its own absorption

Three “prominent” actions of cocaine

Potent local anesthetic, vasoconstrictor (strong constricts blood vessels and raises blood pressure), powerful psychostimulant

Medical Uses of Cocaine

Local anesthetic to control bleed (especially in ear nose throat procedures)

Cocaine Tolerance

DA receptor downregulation, tolerance to euphoric effects develops rapidly

What other clinical disorders co-exist with cocaine dependence?

Anxiety, depression, paranoia, AUD