ONLY IMPORTANT SLIDE OF CD4 Polarization Details!!!

Tfh – polarizing cytokines are IL6 and IL21

Th1 – polarizing cytokine is IL12

Th2 – polarizing cytokine is IL4

Th9 – polarizing cytokines are IL4 and TGFB

Th17 – polarizing cytokines are IL1, IL6, IL23, TGFB

ITreg – polarizing cytokines are IL2 and TGFB

Dendritic cells – what produces the polarizing cytokines

Within T cells – where are the transcription factors that differentiate CD4 subsets

Bcl6 – transcription factor for Tfh

T bet – transcription factor for Th1

GATA3 – transcription factor for Th2

PU.1 – transcription factor for Th9

RORyT – transcription factor for Th17

Foxp3 – transcription factor for iTreg

IL4, IL21 – effector cytokines of Tfh

IFNy, TNFa – effector cytokines of Th1

IL4, IL5, Il13 – effector cytokines of Th2

IL9 – effector cytokines of Th9

IL17, IL22 – effector cytokines of Th17

IL10, TGFB – effector cytokines of iTreg

IL2 – used in combination with polarizing cytokines to differentiation CD4 subsets

Th0 – naïve CD4+ t cell is a ____ cell