Actin filaments

What role does formin play in actin filament assembly?

nucleates assembly and remains associated with the growing plus end.

What does thymosin do in relation to actin filaments?

binds subunits and prevents assembly.

What is the function of tropomodulin?

prevents assembly and disassembly at the minus end.

How does cofilin affect actin filaments?

binds ADP-actin filaments and accelerates disassembly.

What is the primary function of gelsolin?

severs filaments and binds to the plus end.

What do capping proteins do at the plus end of actin filaments?

prevent assembly and disassembly at the plus end.

What is the role of tropomyosin in actin filaments?

stabilizes the filament and modulates binding of other accessory proteins.

How does profilin contribute to actin filament dynamics?

binds monomers and concentrates them at sites of filament assembly.

What does the Arp2/3 complex do regarding actin filaments?

nucleates assembly to form a branched network and remains associated with the minus end.

What are the major functions of actin filaments?

cross-linking, and attachment to membranes.