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Heuristic 1
Remove thermally unstable, corrosive, or chemically reactive components early
Heuristic 2
Remove final products one-by-one as distillates
Heuristic 3
Remove components with high molar percentage early in the sequence
Heuristic 4
Sequence in order of decreasing relative volatility (the most difficult splits are made in the absence of other components)
Heuristic 5
Sequence to leave separations that give highest purity products last
Heuristic 6
sequence to favor near equimolar amounts of distillate and bottoms in each column