Serologically difficult antibodies

What antigens are part of the Diego group?

• Dia/DiB

• Wra/Wrb

Are the Diego antigens co-dominate?

Yes

Which of the Diego antigens are high incidence?

Dib and Wrb

What types of antibodies are anti Wra?

Natural IgM and Immune IgG

What antigens are part of the Cartwright group?

Yta/Ytb (codominant)

Which Cartwright antigen is high incidence?

Yta

What kind of antibodies are anti Yta and Anti Ytb?

Immune mediated (IgG)

What antigens are in the Xg group?

Xga

What chromosome is the Xg group on?

X chromosome

What kind of antibodies are anti Xg?

Immune IgG, rare

What antigens are in the Scianna blood group?

Sc1, Sc2, and Sc3

What Scianna antigen is high incidence?

Sc1

What type of antibodies are anti Scianna?

Immune IgG, rare

What antigens are in the Dombrock group?

• Doa/ Dob (codominant)

• Gya, Hy, Joa

What kind of antibodies are Anti Dombrock?

Immune IgG, rare

anti Doa and Dob react best with enzymes/PEG

What antigens are in the Colton group?

Coa/Cob, Co3 codominant

What kinds of antibodies are anti colton?

Immune IgG, rare

What antigens are in the Chido/rogers group?

6 Chido, 2 Rogers, WH

What system are Chido/Rogers antigen associated with?

The HLA system

What kind of antibodies are anti Chido/Rogers?

High titer low avidity, may interfere with testing

What antigens are in the Gerbich group?

• Ge2, Ge3, Ge4 (high incidence)

• Wb, Lsa, Ana, Dha (low incidence)

What kind of antibodies are Anti Gerbich?

Rare and immune mediated IgG

What antigens are in the Knops group?

Kna, Knb, McCa(McCoy), Sla, Yka (York)

Which Knops antigens are high incidence?

All except Knb

What antigens are in the Indian blood group?

Ina and Inb

What antigens are in the Bg group?

Bga, Bgb and Bgc

Where are Bg antigens primarily located?

One white blood cells

What happens with Bg antibodes?

Are IgG and directed against HLA determinants