polymorphism

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What is a polymorph?

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A different crystalline form of the same compound with distinct packing or conformation.

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Name three physical properties affected by polymorphism?

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Melting point, solubility, density.

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10 Terms

1
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What is a polymorph?

A different crystalline form of the same compound with distinct packing or conformation.

2
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Name three physical properties affected by polymorphism?

Melting point, solubility, density.

3
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What does DSC measure?

Melting points and solid-solid transitions of polymorphs.

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What is the gold standard method for proving polymorphism?

Single crystal X-ray diffraction.

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Why is polymorphism important in pharmaceuticals?

It affects drug bioavailability, stability, and efficacy.

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Which antiviral drug had a crisis due to polymorphism?

Ritonavir.

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What factor can convert a high-energy polymorph into a low-energy one?

Contact with the low-energy form or time during processing.

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What tool helps detect solvent loss in a polymorph?

hot-stage microscopy

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What does TGA measure?

Weight loss as temperature increases (e.g., solvent evaporation).

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What does "bioequivalence" mean in the context of polymorphs?

Different polymorphs may lead to differences in drug absorption and thus therapeutic effect.