What is a polymorph?
A different crystalline form of the same compound with distinct packing or conformation.
Name three physical properties affected by polymorphism?
Melting point, solubility, density.
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What is a polymorph?
A different crystalline form of the same compound with distinct packing or conformation.
Name three physical properties affected by polymorphism?
Melting point, solubility, density.
What does DSC measure?
Melting points and solid-solid transitions of polymorphs.
What is the gold standard method for proving polymorphism?
Single crystal X-ray diffraction.
Why is polymorphism important in pharmaceuticals?
It affects drug bioavailability, stability, and efficacy.
Which antiviral drug had a crisis due to polymorphism?
Ritonavir.
What factor can convert a high-energy polymorph into a low-energy one?
Contact with the low-energy form or time during processing.
What tool helps detect solvent loss in a polymorph?
hot-stage microscopy
What does TGA measure?
Weight loss as temperature increases (e.g., solvent evaporation).
What does "bioequivalence" mean in the context of polymorphs?
Different polymorphs may lead to differences in drug absorption and thus therapeutic effect.