Part 6. Dose-Response Relationship Curves

What are the 4 types of cell survival curves?

1. linear vs non-linear

2. threshold vs non-threshold

Which graph contains linear slopes? Which graph contains non-linear slopes?

1. Linear

2. Non-linear

Which slopes are threshold? Which slopes are non-threshold?

Threshold: c, d, g

Non-threshold: a, b, e, f

label

1. Response (i.e. effect/ side effect/ damage)

2. Radiation Dose

In your own words describe the difference between:

1. linear

2. non-linear

1. linear: straight line (Dose proportional to response)

2. non-linear: not a straight line

In your own words describe the difference between:

1. threshold

2. non-threshold

1. Threshold: dose has to be a certain number to start seeing an effect

2. Threshold: “zero” dose. dose at any number

Most effects we see are (threshold/ non-threshold)

threshold

Give an example of a non-threshold effect

1. genetic mutation

2. cancer formation (in theory)

Give an example of a threshold effect

1. RTM (certain dose for this)

2. Moist desquamation (Certain dose for this)

Dose/Response Curve for radiation protection purposes

non-threshold model

FYI: basically something like “b” . We assume ANY dose can cause harm. So there is no threshold dose allowed for how thick the walls need to be

↑ Dose = __harm/ effect

↑ Dose = ↑ harm/ effect