AED's
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30 Terms
1
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Phenytoin (Dilantin) Basics
\-Traditional AED
\-Suppress sodium
\-Oral
\-Suppress sodium
\-Oral
2
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Phenytoin (Dilantin) Uses
Epilepsy and cardiac dysrhythmia
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Phenytoin (Dilantin) adverse
Sedation, ataxia, gingival hyperplasia, and CV effects
4
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Phenytoin (Dilantin) interactions
Decreases effects of oral contraceptives, warfarin, and glucocorticoids
5
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Fosphenytoin (Cerebyx) basics
Traditional AED
\
Prodrug that is converted to phytoin when metabolized
\
Prodrug that is converted to phytoin when metabolized
6
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Fosphenytoin (Cerebyx) Adverse
temporary parethesis, itching (groin)
7
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Carbamazepine (tegetol) uses
\-epilepsy
\-bipolar
\-neuralgias
\-bipolar
\-neuralgias
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Carbamazepine (tegretol) MOA
suppress neuronal discharge
\
Traditional AED
\
Traditional AED
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Carbamazepine (tegretol) adverse
\-leukopenia
\-anemia
\-thrombocytopenia
\-birth defects
\-photosensitivity
\-anemia
\-thrombocytopenia
\-birth defects
\-photosensitivity
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Carbamazepine (tegretol) interactions
Warfarin, oral contraceptives, grapefruit juice
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Valproic acid (Depa) MOA
Traditional AED
\
Suppresses sodium, suppresses calcium, inhibits GABA
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Suppresses sodium, suppresses calcium, inhibits GABA
12
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Valproic acid (Depa) uses
\-seizures
\-bipolar
\-migraine
\-bipolar
\-migraine
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Valproic acid (Depa) adverse
\-hepatotoxicity
\-teratogenic effects
\-teratogenic effects
14
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Valproic acid (Depa) interactions
phenytoin, topiramate, meropenem, phenobarbital
15
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Ethosuximide (Zarontin) uses
absence seizures!
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Ethosuximide (Zarontin) MOA
Traditional AED
\
Suppresses neurons in the thalamus
\
Suppresses neurons in the thalamus
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Ethosuximide (Zarontin) adverse and interactions
none
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Ethosuximide (Zarontin) common side effects
drowsiness, dizziness, and lethargy
19
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Phenobarbital actions and uses
Traditional AED
\-reduces seizures with no sedation
\- anticonvulsant barbiturate
\
\-epilepsy
\-sedation
\-reduces seizures with no sedation
\- anticonvulsant barbiturate
\
\-epilepsy
\-sedation
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Phenobarbital adverse
\-Psychologic disorders
\-rickets
\-nystagmus
\-ataxia
\-rickets
\-nystagmus
\-ataxia
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Phenobarbital interactions
Oral contraceptives, warfarin,
\
causes drug withdrawal
\
causes drug withdrawal
22
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Primidone (Mysoline)
tradtional AED
VERY SIMILAR TO PHENOBARBITAL
\
active against all major seizure disorders EXCEPT absence
VERY SIMILAR TO PHENOBARBITAL
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active against all major seizure disorders EXCEPT absence
23
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Oxcarbazepine uses
Newer AED
\
therapy of partial seizures in adults and children
\
therapy of partial seizures in adults and children
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Oxcarbazepine adverse
\-dizziness, double vision, nystagmus, headache, nausea, ataxia
\-stevens Johnson
\-Toxic epidermal necrolysis
\-stevens Johnson
\-Toxic epidermal necrolysis
25
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Lamotrigine (lamictal) use and adverse
New AED
\
Uses
\-broad antiseizure
\-Bipolar
Adverse
\-severe skin reactions
\-suicide risk
\
Uses
\-broad antiseizure
\-Bipolar
Adverse
\-severe skin reactions
\-suicide risk
26
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gabapentin (neutronin) uses and adverse
new aed
\
Uses
\-partial seizures
\-neuro pain, migraine, fibromyalgia, hot flashes
Adverse
\-well tolerated
\-somnolence
\
Uses
\-partial seizures
\-neuro pain, migraine, fibromyalgia, hot flashes
Adverse
\-well tolerated
\-somnolence
27
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Pregabalin (Lyrica) uses
New Aed
\
\-nuero pain associated with diabetes
\-partial seizures
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\-nuero pain associated with diabetes
\-partial seizures
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Pregabalin (Lyrica) adverse
\-Somnolence
\-Rhabdomyolysis
\
POTENTIAL for ABUSE
\-Rhabdomyolysis
\
POTENTIAL for ABUSE
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Levetiracetam (Keppra) Basics
\-New AED
\-Unique, different from other AED
\-Adverse affects are mild-moderate
\-Doesnt interact with other AEDs
\-Unique, different from other AED
\-Adverse affects are mild-moderate
\-Doesnt interact with other AEDs
30
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Lacosamide (Vimpat) basics
\-New AED
\-Used for partial seizures in 17+ patients
\-Adverse = small risk for suicidal thoughts/behavior
\-Used for partial seizures in 17+ patients
\-Adverse = small risk for suicidal thoughts/behavior