Chapter 1: Introduction to Disease

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vocab, important information, practice problems

92 Terms

1

Health

the condition in which the human body performs its vital functions normally; the body's various organ systems function optimally

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2

Homeostasis

A state of balance among all the body systems needed for the body to survive and function correctly; the body's organ systems normally maintain temperature, pH, blood composition, and fluid levels in a precise range and correct any fluctuations before they harm the body

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3

What does health depend on?

homeostasis

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4

Disease

a significant disturbance in the homeostasis of the body; a deviation from normal structure or function in the body that interrupts or modifies the performance of vital functions

(ex) diabetes

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5

Pathology

the study of disease, especially the structural and functional changes associated with disease; the study of its causes, mechanisms, signs and symptoms, treatments, and prevention

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6

Pathologist

a physician who studies and interprets the changes cause by disease; examining cells, tissues, organs, and lab test results

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7

How can a disease be recognized?

through its characteristic signs and symptoms

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8

Signs

evidence of disease observed on physical examination

(ex) abnormal pulse or respiratory rate, fever, and sweating

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9

Symptoms

indications of disease reported by the patient

(ex) pain, dizziness, and itching

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10

Asymptomatic Disease

a disease that causes no signs or symptoms

(ex) chlamydia

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11

Syndrome

an abnormal structure or function characterized by a group of signs and symptoms that usually go together

(ex) AIDS, malabsorption syndrome, down syndrome

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12

Disorder

functional abnormality not necessarily linked to a specific cause or physical abnormality

(ex) adhd, premenstrual dysphoric disorder, and hemorrhoids

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13

Do disorders need to be accompanied by specific signs and symptoms?

No. Disorders might be accompanied by specific signs and symptoms, but their presence is NOT required for a condition to be termed a disorder

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14

Diagnosis

the process of identifying a disease or disorder

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15

What are several different types of information that can be used for a diagnosis?

  1. Signs and Symptoms (acquired through physical examination and interviews with a patient or patient's family)

  2. Course and history of signs and symptoms

  3. Results of laboratory tests (analysis of the composition of urine, blood, throat swabs, stool, sputum, etc)

  4. Biopsy

  5. Imaging technologies (ECG, CT, MRI, Ultrasound, etc)

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16

What occurs during a physical exam?

  1. Inspection

  2. Palpation

  3. Auscultation

  4. Percussion

  5. Vital signs

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17

Inspection

a visual examination of the external surface of the body, its movements, and posture for abnormalities and/or evidence of disease

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18

Palpation

feeling the body with fingers/hands; allows examination of the size consistency, texture, location, and tenderness of an organ or body part

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19

Auscultation

Listening to the lungs, heart, and intestines; allows evaluation of the frequency, intensity, duration, number, and quality of sounds originating in the body.

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20

Percussion

producing sounds by tapping on specific areas of the body with fingers, hands, or a small instrument; allows for evaluation of the size, consistency and borders of the body organs and the presence or absence of fluid in body areas.

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21

Vital Signs

pulse, respiratory rate, blood pressure, and temperature are measures of various physiological statistics in order to assess the most basic body functions; normal vital signs vary with age, sex, weight, exercise tolerance, and physical condition

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22

Biopsy

surgical removal and analysis of tissue samples

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23

What does a electrocardiogram (ECG) do?

reads the heart's electrical impulses

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24

What does a radiography do?

uses x-rays to visualize internal structures

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25

What does a computed tomography (CT) scan do?

uses computers and x-rays to create 3-dimensional images of internal structures

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26

What does magnetic resonance imaging (MRI) do?

analyzes tissue responses to a strong magnetic field to create images of internal structures

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27

What does an ultrasound do?

analyzes the interaction of low-frequency sound waves with tissues to create moving images of internal organs

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28

What does nuclear medicine do?

uses radioactive materials to create contrast in the body and help form images of the structure and function of organs

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29

Prognosis

the predicted course and outcome of a disease; can state the chances for complete recovery, predict the permanent loss of a function, or give probability of survival

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30

acute diseases

diseases that have a sudden onset and short duration

(ex) Influenza, measles, the common cold

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31

terminal diseases

diseases that will end in death

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32

Chronic diseases

diseases that have a slower, less severe onset and a long duration of months or years

(ex) heart disease, cancer, stroke, diabetes, arthritis

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33

What are the ten leading causes of death in the world?

  1. Ischemic heart disease

  2. stroke and other cerebrovascular disease

  3. lower respiratory infections

  4. chronic obstructive pulmonary disease

  5. diarrheal disease

  6. HIV/AIDS

  7. Trachea, bronchus, lung cancers

  8. Tuberculosis

  9. Diabetes

  10. Road traffic accidents

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34

What is/are the leading cause(s) of death in wealthy western countries?

Chronic diseases = Overall

1. Ischemic heart disease

2. Stroke and other cerebrovascular disease

3. Trachea, bronchus, lung cancers

4. Alzheimer's and other dementias

5. Lower respiratory infections

6. Chronic obstructive pulmonary disease

7. Colon and rectum cancers

8. Diabetes mellitus

9. Hypertensive heart disease

10. Breast cancer

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35

What is/are the leading cause(s) of death in low income countries?

Infectious diseases = Overall

1. Lower respiratory infections

2. Diarrhea disease

3. HIV/AIDS

4. Ischemic heart disease

5. Malaria

6. Stroke and other cerebrovascular disease

7. Tuberculosis

8. Prematurity and low birth weight

9. Birth asphyxia and birth trauma

10. Neonatal infections

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36

Remission

a period which a disease signs and symptoms subside or disappear; not a cure and can last for days, months, or years, and can recur anytime

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37

Exacerbation

increase in the severity of a diseases' signs and symptoms

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38

Can diseases be characterized by periods of remission, recurrence, and exacerbation?

Yes. For example, leukemia and ulcerative colitis are characterized by periods of remission, recurrence, and exacerbation.

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39

Relapse

the return of a disease weeks or months after its apparent cure

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40

Complication

a related disease or other abnormal state that develops in a person already suffering from a disease; may interfere with recovery from the original disease

(ex) anemia is a complication of leukemia

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41

Sequela/Sequel

the aftermath of a particular disease

(ex) a sequela of rheumatic fever is permanent damage to the heart

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42

Is the number of deaths caused by a disease important to monitor?

Yes, even it causes very few deaths.

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43

Morality

the number of deaths that occur among people with a certain disease

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44

Morbidity

the number of cases of a disease in a population; the incidence of disease

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45

Prevalence

the percentage of a population that is affected with a particular disease at a given time

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46

What are the uses of pervalence data?

1. It allows the determination of the impact and significance of a disease for a population

2. Used to direct health. care resources and research

3. See the significance of certain disease for certain demographics

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47

Epidemiology

the study of the occurrence, transmission, distribution, and control of disease

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48

Etiology

the cause(s) of a disease

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49

Pathogenesis

describes how the cause of a disease leads to anatomical and physiological changes in the body that ultimately result in the disease

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50

Idiopathic Disease

a disease in which the cause is unknown

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51

What are the major categories of diseases?

1. Hereditary diseases

2. Congenital diseases

3. Degenerative diseases

4. Inflammation/autoimmunity/allergy

5. Infectious diseases

6. Neoplastic diseases

7. Metabolic diseases

8. Trauma

9. Nutritional-imbalance diseases

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52

Hereditary disease

Abnormality in an individual's genes or chromosomes.

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53

Congenital disease

Exist at or date from birth; can be acquired through heredity or acquired during development in the uterus.

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54

Degenerative disease

Function or structure of the affected tissues or organs progressively deteriorates over time.

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55

Inflammation/autoimmunity/allergy

Result of abnormal immune function

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56

Infectious disease

caused by pathogens such as bacteria and viruses

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57

Neoplastic disease

Result from abnormal growth that leads to the formation of tumors

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58

Metabolic disease

Disruption of normal metabolism, the process of converting food to energy on a cellular level.

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59

Trauma

Physical or chemical injury.

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60

Nutritional-imbalance disease

Over or under consumption of nutrients.

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61

Does a risk factor decrease a person's chance of developing disease?

No, it increases it

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62

Is a risk factor equivalent to etiology?

No

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63

If a person has (a) certain risk factor(s) for a disease, will they immediately acquire the disease?

No, it just increases the risk for developing that disease.

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64

If a person eliminates known risk factors for a disease, will that lower the chance of developing that disease?

yes

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65

What are the categories of risk factors?

genetic, environmental, chemical, physiological, and psychological

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66

What are the four modifiable risk factors that are responsible for much of the illness, disability, and premature death related to chronic diseases?

Lack of physical activity, poor nutrition, tobacco use, and excessive alcohol consumption

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67

Moderate alcohol consumption is defined as how many drinks per day for men? For women?

2 drinks per day for men and 1 drink per day for women

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68

How many times per week should you engage in strength and flexibility training?

at least 2 times per week

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69

How many minutes of vigorous-intensity aerobic activity does an adult need to do per week?

75 minutes

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70

How much of your healthy plate should be fruits and vegetables?

half your plate

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71

What are a few simple steps to decrease the risk for diseases and promote long, health lives?

-Be physically active

-Eat wisely

-Maintain a health weight

-Be tobacco free

-limit alcohol

-get recommended screening tests and immunizations

-manage stress

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72

What is the goal of treatment?

treatment aims to cure a disease or reduce the severity of its signs and symptoms; not all diseases are curable

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73

What is the goal of palliative treatment?

provide comfort and relieve pain

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74

Doe treatment include medical (pharmacologic) procedures?

Yes, treatment uses specific drugs to cure or relieve signs and symptoms. For example, antibiotics kill the bacteria that cause pneumonia.

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75

Some athletes may develop abnormally high red blood cell counts. Why? In the athlete's case, is this a sign of disease?

Abnormally high red blood cell counts can and do occur in well-trained athletes. Athletes develop increased cardiovascular efficiency and produce more red blood cells. Their hearts can handle the slightly increased viscosity of the blood and thus higher red blood cell levels may not be a sign of disease.

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76

Chronic diseases and their major risk factors place huge economic demands on our nation. For example, from 1987 to 2001 increases in obesity prevalence alone accounted for 12% of the growth in health care spending. What factors may have contributed to this increase in obesity in the United States? What is being done or what could be done to reverse the trend?

Obesity is the result of an energy imbalance; eating too many calories and not getting enough physical activity. Body weight may be the result of genetics, metabolism, behavior, environment, culture, and socioeconomic status. Behavior and environment are the key areas in obesity prevention.

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77

A patient reports to her physician that she feels weak and dizzy. Is this enough information to make a diagnosis? What other sources of information can her physician consult?

No. Many diseases share these symptoms. A simple history can determine if she ate recently or if she is under stress, depressed, or anxious, and a blood test can determine her sugar levels and the presence of diabetes. The physician can consult a blood test to determine anemia or other blood disorders. A physical exam can determine whether she has hypertension. Cardiovascular abnormalities can be determined with a physical exam or with imaging techniques. In short, several diseases can explain these symptoms.

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78

A skin rash is an example of a ____________________.

a. sign

b. symptom

c. laboratory result

d. syndrome

a. sign

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79

A(n) ____________________ disease has a sudden onset and short course.

a. acute

b. terminal

c. chronic

d. idiopathic

a. acute

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80

The cause of a disease is known as its ____________________.

a. pathogenesis

b. complication

c. sequela

d. etiology

d. etiology

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81

The condition in which the human body performs its vital functions normally is known as ____________________.

a. health

b. disease

c. disorder

d. homeostasis

a. health

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82

Signs and symptoms grow more severe in a period known as ____________________.

a. remission

b. exacerbation

c. relapse

d. complication

b. exacerbation

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83

True or False: Homeostasis refers to the process of identifying a disease from its signs and symptoms.

False

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84

True or False: Mortality refers to the number of deaths caused by a disease.

True

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85

True or False: Symptoms are objective evidence of a disease.

False

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86

True or False: Signs may be perceived by the physician.

True

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87

True or False: Remission and relapse may characterize a chronic disease.

True

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88

The predicted outcome of a disease is its ____________________.

prognosis

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89

Diseases with a rapid onset and resolution are called ____________________ diseases.

acute

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90

If the cause of a disease is not known, it is said to be ____________________.

idiopathic

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91

Return of symptoms after their apparent cessation is ____________________.

relapse

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92

The signs and symptoms of a chronic disease at times subside during a period known as ____________________.

remission

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