PHRM 825 Exam 2 - progestins (drugs)

high oral bioavailability, IUDs, PlanB

Levonorgestrel

Prodrug, converted to levonorgestrel

norgestimate

prodrug, high oral bioavailability, rapidly metabolized to etonogestrel

desogestrel

subdermal implant or vaginal ring

etonogestrel

relatively weak progestogenic, antimineralocorticoid activity, less side effects than more BC

drospirenone

used as depot injection - long-acting progesterone-only contraceptive

medroxyprogesterone acetate

example of other steroids that can interact with OC

glucocorticoids

what happens in use OC and other steroids

increase the blood levels by interfering their metabolism

what happen when using phenytoin (anticonvulsants) and OC together

induced drug-metabolizing enzymes in the lover

what happens when using rifampin (antibiotic) and OC together

induced drug metabolizing enzymes in the liver, increase rate metabolism of many other drugs

when happens when using tetracyclines and OC together

suppresses gut flora that participate in enterohepatic recycling

combination postcoital contraception

Ovral, Preven (ethinyl estradiol + norgestrel)

progestin postcoital contraception

PlanB

side effects of postcoital contraception

nausea, vomiting is more common

SPRM, emergency contractive, up to 5 days after

ulipristal acetate

progesterone antagonist, abortifacient, used in combination with misoprostol

mifepristone

weak androgen, weak progesting, antiestrogen, endometriosis

danazol