Infectious Disease Unit 1: Cephalosporins

B-hemolytic Streptococcus sp.

Empiric:

• Cefazolin

• Cephalexin

• Cefuroxime

• Ceftriaxone

• Cefepime

• Ceftaroline

S. pneumoniae

Empiric:

• Ceftriaxone

• Cefepime

• Ceftaroline

Targeted:

• Cefazolin, Cephalexin ,Cefuroxime, Ceftazidime

MSSA

Empiric:

• Cefazolin

• Cephalexin

• Cefuroxime

• Cefepime

• Ceftaroline

MRSA

Empiric:

• Ceftaroline

VSE

Targeted:

• Ceftaroline

VRE

No CEPHALOSPORIN activity (VRE)

Atypicals (CML)

No CEPHALOSPORIN activity (CML)

H. influenzae, M. catarrhalis

Empiric (all cephalosporins)

• cefazolin

• cephalexin

• cefuroxime

• cefoxitin

• ceftriaxone

• ceftazidime

• cefepime

• ceftaroline

EB (non-ESBL)

Empiric:

• Cefoxitin

• Ceftriaxone

• Ceftazidime

• Cefepime

• Ceftaroline

EB with ESBL

Targeted:

• Cefoxitin

• Cefepime

EB with AmpC

Empiric:

• Cefepime

CRE- Carbapenem-Resistant Enterobacterales

No CEPHALOSPORIN Activity (CRE)

P. aeruginosa

Empiric:

• Ceftazidime

• Cefepime

Acinetobacter sp.

Targeted:

• Ceftazidime

• Cefepime

Gram-negative anaerobes

Targeted:

• Cefoxitin