Pharmacology - Anti-microbials

Folate Production and Metabolism

Sulfonamides

Amoxicillin - beta lactum

Cell Wall - inhibits transpeptidases

Cephalexin - beta lactam

Cell Wall - inhibits transpeptidases

Vancomycin - glycopeptides

Cell Wall - inhibits transglycosidases - MR Staph Aureus - Red Man syndrome

Cell Wall targets PCV

Penicillin

cephalosporins

vancomycin

Erythromycin - Macrolide

Protein synthesis- interefere with ribosome movement

Clarithromycin - Macrolide

Protein synthesis- interefere with ribosome movement

Gentamycin - Aminoglycosides

Protein synthesis - Misreading of mRNA

Doxycycline - Tetracyclines

Protein Synthesis - interfere with tRNA binding - black teeth + Malaria treatment

Protein Synthesis targets TAM

Tetracyclines

Aminoglycosides

Macrolides

Ciprofloxacin - Flouroquinolone

Nucleic Acid Synthesis - Inhibits topoisomerase

Metronizadole- Nitroimidazole

Nucleic acid synthesis - inhibits DNA synthesis

Rifampicin - Anti-mycobacterial

Nucleic acid synthesis - inhibits RNA synthesis - TB

Isoniazid - Anti-mycobacterial

Mycolic Acid synthesis - TB

Nucleic Acid synthesis targets NAF

Nitroimidazoles

Anti-mycobacterials

Flouroquinolones

ANTIVIRAL - Ritonavir

Viral Release - inhabits viral protease

ANTIVIRAL - Oseltamivir

Viral Release - inhabits neuraminadase

ANTIVIRAL - Tenofovir (Retro viruses)

Nucleic Acid Synthesis. - Inhibits reverse transcriptase

ANTIVIRAL - acyclovir - herpes

Nucleic Acid Synthesis. - Inhibits DNA polymerase

ANTIFUNGAL - Fluconazole

Plasma membrane - inhibits ergosterol synthesis

no aspergillus

ANTIGUNGAL - Amphotericin B - Polyene

Disrupts plasma membrane

ANTIGUNGAL - Caspofungin

Cell wall synthesis

ANTIPARASITIC - Atovaquone

Disrupts ETC - Malaria

Treat and prevent Pneumocystis jirovecii pneumonia (PCP)

ANTIPARASITIC - Quinine

Disrupts haemoglobin metabolism - Malaria