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58 Terms

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DNA

Deoxyribonucleic acid: a molecule in cells that contains the genetic instructions for an organisms development and function

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RNA

A nuclei acid that carries genetic information copied from DNA.

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mRNA

A single stranded molecule that carries genetic instructions from DNA in the nucleus to the cytoplasm where proteins are made

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tRNA

A type of RNA molecule that helps decode a messenger RNA sequence into a protein

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rRNA

A non coding RNA that forms the structural framework of ribosomes

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Nitrogen base

A molecule that contains nitrogen and has the chemical properties of a base

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epistasis

the description of how gene interactions can impact phenotypes or how one gene’s expression can be modified by another

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RNA polymerase

a complex enzyme that transcribes DNA into RNA

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RNA primer

a short, single-stranded RNA segment that acts as a starting point for DNA synthesis.

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primase

an enzyme involved in the replication of DNA and is a type of RNA polymerase. Primase catalyzes the synthesis of a RNA primer

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helicase

an enzyme that unwinds the double-stranded DNA molecule by breaking the hydrogen bonds between base pairs

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operator

regulatory DNA elements that control transcription initiation. A segment of DNA where the repressor binds to preventing the transcription of certain genes

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pyrimidine

pyrimidines (cytosine and thymine) are one-carbon nitrogen ring bases.

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purine

Purines (adenine and guanine) are two-carbon nitrogen ring bases

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intron

noncoding DNA sequences within genes that are removed before the RNA molecule is translated into a protein.

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exon

the coding portions of DNA or RNA

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splicing

a biological process where a newly synthesized pre-mRNA is transformed into a mature mRNA. It occurs during protein synthesis and involves the removal of non-coding sequences and then joining the coding regions

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ligase

an enzyme that can catalyze the joining (ligation) of two molecules by forming a new chemical bond

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leading strand

a strand of DNA that replicates continuously without stopping

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lagging strand

a strand of DNA that replicates discontinuously, stopping and then starting again.

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telomeres

structures made from DNA sequences and proteins found at the ends of chromosomes

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telomerase

a enzyme that adds nucleotides to telomeres, especially in cancer cells

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3’ to 5’

the number of carbon atoms in a DNA sugar molecule

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5’ to 3’

the bases in the DNA which are only read and synthesized 5’ to 3’

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hydrogen bond

a polar bond between hydrogen and another electronegative atom

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ozakai fragments

small sections of DNA that are formed during discontinuous synthesis of the lagging strand during DNA replication

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nucleic acid

an organic substance whose molecules consist of many nucleotides linked in a long chain.

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active site

the region of an enzyme where substrate molecules bind and undergo a chemical reaction.

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transcription

the process of copying a segment of DNA into RNA for the purpose of gene expression.

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TATA box

a DNA sequence that indicates where a genetic sequence can be read and decoded. It is a type of promoter sequence.

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template strand

the strand that is used during transcription to produce RNA.

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codon

a DNA or mRNA sequence of three nucleotides that forms a unit encoding a particular amino acid or signaling the termination of protein synthesis held in the coding strand.

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anticodon

a sequence of three nucleotides in transfer RNA that binds to a corresponding codon and designates a specific amino acid, held in the template strand

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coding strand

the DNA strand whose base sequence is similar to its primary transcript (RNA)

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start codon

the initial set of codons in an mRNA transcript that is translated by a ribosome. In eukaryotes, the most common start codon is AUG

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stop codon

a sequence of three nucleotides in DNA or mRNA that signals a stop to protein synthesis in the cell.

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nucleotide

the basic building block of nucleic a. It consists of a sugar molecule, either ribose or deoxyribo, attached to a phosphate group and a nitrogen-containing base.

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5 carbon sugar

5 carbon sugars, aka pentose, are types of carbohydrates that contain five carbon atoms in their molecular structure. These sugars play a crucial role in forming nucleotides

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phosphate

A form of phosphoric acid, which contains phosphorus

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histones

a protein that provides structural support for a chromosome

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semiconservative replication

process in which two copies of the original DNA molecule are produced, each copy replicating the information from one half of the original DNA molecule

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a Y-shaped region where the parent DNA double helix splits into two strands to be copied

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mutation

Any change in the DNA sequence of a cell

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point mutation

a genetic alteration that occurs when a single base pair in an organism's DNA or RNA sequence is changed, deleted, or inserted

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frame shift mutation

a genetic mutation that occurs when bases are inserted or deleted from a DNA sequence in a number that isn't three

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transformation

a process in which foreign DNA is introduced into bacterial cells, resulting in the acquisition of new genetic traits.

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transformation experiment

an experiment preformed by Frederick Griffith in 1928, which was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.

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capsid

the protein shell of a virus, enclosing its genetic material.

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viral envelope

a lipid bilayer membrane that surrounds the capsid of some viruses, protecting their genetic material as they travel between host cells

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bacteriophage

viruses that infect and replicate within bacteria and archaea

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lytic phase

the virus introduces its genome into a host cell and initiates replication by hijacking the host's cellular machinery to make new copies of the virus.

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lysogenic phase

viruses sneak into the host's DNA, stay hidden, and wait. Later, they become active, make copies, and infect other cells.

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names of people involved in DNA

james watson, Francis crick, Rosalind Franklin, Erwin Chargaff, Maurice Wilkins, Hershey and Chase

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watson and crick

discovered the DNA double helix

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Rosalind franklin

discovered the structure of DNA

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erwin chargaff

discovered that in DNA the ratios of adenine to thymine and guanine to cytosine are equal.

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maurice wilkins

also helped discover the double helix in dna

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hershey and chase

helped confirm that DNA is genetic material