According to the International Society of Blood Transfusion, how many are the blood Group System?
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371
According to the International Society of Blood Transfusion, how many are the Blood Group Antigen?
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Blood Group antigens
Defined as carbohydrates (sugars) attached to glycoprotein or glycolipid structures or by amino acids on a protein
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* Carbohydrate Antigen / Protein Antigen
* Low Incidence / High Incidence (according to occurrence)
Blood group antigens are classified as: 4
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How are Genes written?
written in italics /underlined, number is SUPERSCRIPT
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How are Antigens written?
Written in regular type (some antigens have numbers or superscript letters)
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How are Phenotypes written?
Allele number is SUBSCRIPT
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For letter antigens…
a plus sign or minus sign written on the same line as the antigen is used to designate that the antigen is present or absent
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For antigens that have superscripts…
the letter of the superscript is placed in parentheses on the same line as the letter defining the antigen
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For antigens that have a numerical designation…
the letter(s) defining the system is followed by a colon, followed by the number representing the antigen
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semicolon
Phenotypes of more than one blood group system are separated by a ___________
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antibodies
Described by their antigen notation with the prefix anti-, including a hyphen before the antigen symbol
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Correct
Identify if correct or incorrect terminology:
Fy(a+)
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Correct
Identify if correct or incorrect terminology: M+ and K-
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Incorrect
Identify if correct or incorrect terminology:
Fya-b+
\ \* a-b+ is in superscript
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Incorrect
Identify if correct or incorrect terminology, and why?
\ Anti Fya
\*a is in superscript
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Incorrect
Identify if correct or incorrect terminology:
Anti-Duffya
\*a is in superscript
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Incorrect
Identify if correct or incorrect terminology:
Fya (-)
\*a is in superscript
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Correct
Identify if correct or incorrect terminology:
Fy(a+) and Jk (a-)
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Correct
Identify if correct or incorrect terminology:
Sc: -1,2
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Correct
Identify if correct or incorrect terminology:
S+s+; K-; Fy(a+b-)
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negative (absence of the antigen)
presence of minus sign
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positive (presence of antigen)
denoted with + sign
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molecular studies
If you want to perform patient genotype, perform _____________
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Does serological tests determine genotype?
NO, because serologic tests determine only the RBC phenotype. For the genotype, perform molecular studies.
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Genotype
composed of actual genes that an individual has inherited and can determined only by family or DNA studies
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What is the function of the International Society of Blood Transfusion?
To facilitate computer storage and retrieval of blood group information and to help standardize blood group system and antigen names.
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ISBT
WORKING PARTY ON TERMINOLOGY FOR RED CELL SURFACE ANTIGENS
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ISBT
Enable communication on computer systems where numbers are necessary
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First three digits represent
the system, collection, or series
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Second three digits
identify the antigen
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system
Consists of one or more antigens controlled at a single gene locus, or by two or more very closely linked homologous genes with little or no observable recombination between them.
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Collections
Antigens that have a biochemical, serologic, or genetic relationship but do not meet the criteria for a system
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700 and 901
All remaining RBC antigens that are not associated with a system or a collection are catalogued into the __ series of low prevalence antigens or the _ series of high-prevalence antigens
\ Answer in: # , #
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Low Incidence
represents prevalence of
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High incidence
>90% of most random population
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In terms of Immunogenicity which blood group is the most immunogenic?
A,B
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In terms of Immunogenicity which blood group is the seconds most immunogenic?
Rh D
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In terms of Immunogenicity which blood group is the third most immunogenic?
Kell group
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In terms of Immunogenicity which blood group is the fourth most immunogenic?
Duffy group
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What are the blood groups destroyed by enzyme treatment?
Duffy (Fya /Fyb), MNS Xg (Xga ), Chido Rodgers
\ DaMN SeXy Chido Rodgers
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What are the blood groups enhanced by enzyme treatment?
P1, A, Rh, Kidd (JKa /JKb ), Lewis (Lea /Leb )
\ PIA at Rhea may Kidd at si Lewis ang ama
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Examples of Enzyme:
Ficin, Papain, Trypsin, and Bromelin
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Which blood group is unaffected by enzyme treatment?
Kell group
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Antibodies to antigen of following blood groups are known for showing dosage: