IMH_100: Other blood groups part 1

0.0(0)
studied byStudied by 2 people
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
Card Sorting

1/173

flashcard set

Earn XP

Description and Tags

Study Analytics
Name
Mastery
Learn
Test
Matching
Spaced

No study sessions yet.

174 Terms

1
New cards

45

According to the International Society of Blood Transfusion, how many are the blood Group System?

2
New cards
371
According to the International Society of Blood Transfusion, how many are the Blood Group Antigen?
3
New cards
Blood Group antigens
Defined as carbohydrates (sugars) attached to glycoprotein or glycolipid structures or by amino acids on a protein
4
New cards
* Carbohydrate Antigen / Protein Antigen


* Low Incidence / High Incidence (according
to occurrence)
Blood group antigens are classified as: 4
5
New cards
How are Genes written?
written in italics /underlined, number is SUPERSCRIPT
6
New cards
How are Antigens written?
Written in regular type (some antigens have numbers or superscript letters)
7
New cards
How are Phenotypes written?
Allele number is SUBSCRIPT
8
New cards
For letter antigens…
a plus sign or minus sign written on the same line as the antigen is used to designate that the antigen is present or absent
9
New cards
For antigens that have superscripts…
the letter of the superscript is placed in parentheses on the same line as the letter defining the antigen
10
New cards
For antigens that have a numerical designation…
the letter(s) defining the system is followed by a colon, followed by the number representing the antigen
11
New cards
semicolon
Phenotypes of more than one blood group system are separated by a ___________
12
New cards
antibodies
Described by their antigen notation with the prefix anti-, including a hyphen before the antigen symbol
13
New cards
Correct
Identify if correct or incorrect terminology:

Fy(a+)
14
New cards
Correct
Identify if correct or incorrect terminology: M+ and K-
15
New cards
Incorrect
Identify if correct or incorrect terminology:

Fya-b+

\
\* a-b+ is in superscript
16
New cards
Incorrect
Identify if correct or incorrect terminology, and why?

\
Anti Fya

\*a is in superscript
17
New cards
Incorrect
Identify if correct or incorrect terminology:

Anti-Duffya

\*a is in superscript
18
New cards
Incorrect
Identify if correct or incorrect terminology:

Fya (-)

\*a is in superscript
19
New cards
Correct
Identify if correct or incorrect terminology:

Fy(a+) and Jk (a-)
20
New cards
Correct
Identify if correct or incorrect terminology:

Sc: -1,2
21
New cards
Correct
Identify if correct or incorrect terminology:

S+s+; K-; Fy(a+b-)
22
New cards
negative (absence of the antigen)
presence of minus sign
23
New cards
positive (presence of antigen)
denoted with + sign
24
New cards
molecular studies
If you want to perform patient genotype, perform _____________
25
New cards
Does serological tests determine genotype?
NO, because serologic tests determine only the RBC phenotype. For the genotype, perform molecular studies.
26
New cards
Genotype
composed of actual genes that an individual has inherited and can determined only by family or DNA studies
27
New cards
What is the function of the International Society of Blood Transfusion?
To facilitate computer storage and retrieval of blood group information and to help standardize blood group system and antigen names.
28
New cards
ISBT
WORKING PARTY ON TERMINOLOGY FOR RED CELL SURFACE ANTIGENS
29
New cards
ISBT
Enable communication on computer systems
where numbers are necessary
30
New cards
First three digits represent
the system, collection, or series
31
New cards
Second three digits
identify the antigen
32
New cards
system
Consists of one or more antigens controlled at a single gene locus, or by two or more very closely linked homologous genes with little or no observable recombination between them.
33
New cards
Collections
Antigens that have a biochemical, serologic, or genetic relationship but do not meet the criteria for a system
34
New cards
700 and 901
All remaining RBC antigens that are not associated with a system or a collection are catalogued into the __ series of low prevalence antigens or the _ series of high-prevalence antigens

\
Answer in: # , #
35
New cards
Low Incidence
represents prevalence of
36
New cards
High incidence
>90% of most random population
37
New cards
In terms of Immunogenicity which blood group is the most immunogenic?
A,B
38
New cards
In terms of Immunogenicity which blood group is the seconds most immunogenic?
Rh D
39
New cards
In terms of Immunogenicity which blood group is the third most immunogenic?
Kell group
40
New cards
In terms of Immunogenicity which blood group is the fourth most immunogenic?
Duffy group
41
New cards
What are the blood groups destroyed by enzyme treatment?
Duffy (Fya /Fyb), MNS Xg (Xga ), Chido Rodgers

\
DaMN SeXy Chido Rodgers
42
New cards
What are the blood groups enhanced by enzyme treatment?
P1, A, Rh, Kidd (JKa /JKb ), Lewis (Lea /Leb )

\
PIA at Rhea may Kidd at si Lewis ang ama
43
New cards
Examples of Enzyme:
Ficin, Papain, Trypsin, and Bromelin
44
New cards
Which blood group is unaffected by enzyme treatment?
Kell group
45
New cards
Antibodies to antigen of following blood groups are known for showing dosage:

1. Rh (except D)
2. Kidd
3. Duffy
4. MNSs
5. Lutheran

\
Rich Kid Doesn’t Mind Losing!
46
New cards
Plasmodium falciparum
Absence of M and N Blood Group is resistant towards
47
New cards
McLeod phenotype having a Chronic Granulomatous Disease
If the person has the presence of the Blood Group Kell then thre is a possibility of having
48
New cards
Plasmodium vivax and Plasmodium knowlesi
Absence of Duffy Blood Group is resistant towards -- and --
49
New cards
0
During the antibody screening test, the initial reaction is 3+, but if an enzyme is added to MN blood group what will be the final reaction?
50
New cards
4+
During the antibody screening test, the initial reaction is 3+, but if an enzyme is added to Kidd blood group what will be the final reaction?
51
New cards
3+
During the antibody screening test, the initial reaction is 3+, but if an enzyme is added to Kell blood group what will be the final reaction?
52
New cards
enzymes; destroy or enhance
In antibody panel identification, we use -- to treat RBC antigens. It can either -- or --- the reaction.

\
Answer: --; -- or --
53
New cards
1
What is the chromosomal location of blood groups:

Rh Duffy, Knops, Scianna, Cromer?
54
New cards
2
What is the chromosomal location of blood groups: MNSs
55
New cards
6
What is the chromosomal location of blood groups: Ii, Chido, Rodgers
56
New cards
7
What is the chromosomal location of blood groups: Kell, Cartwright, Colton
57
New cards
9
What is the chromosomal location of blood groups: ABO
58
New cards
17
What is the chromosomal location of blood groups: Diego
59
New cards
18
What is the chromosomal location of blood groups: Kidd
60
New cards
19
What is the chromosomal location of blood groups:

Lutheran, Lewis, Landsteiner, and Wiener (LW,) H, OK
61
New cards
X
What is the chromosomal location of blood groups: Xg
62
New cards
ABH and Lewis
Sources of Soluble Antigens for Hemagglutination

Inhibition: What blood groups are seen in saliva?
63
New cards
Hydatid cysts (Echinococcus granulosus)
Sources of Soluble Antigens for Hemagglutination

Inhibition: Where are the P1 blood groups seen?
64
New cards
Mixed-field reaction (urine)
Sources of Soluble Antigens for Hemagglutination

Inhibition: Where are the Sd^a blood groups seen?
65
New cards
milk for infants
Sources of Soluble Antigens for Hemagglutination

Inhibition: Where is the Ii blood groups seen?
66
New cards
Lewis (007) LE System
Not intrinsic to RBCs
67
New cards
19
Lewis gene is found in which chromosome number? #only
68
New cards
fucosyl transferase enzyme
Le (FUT3) gene codes for the production of --
69
New cards
In the Lewis system, what are adsorbed in the RBC membrane?
Type 1 glycosphingolipids
70
New cards
Tissues
\-- are responsible for the production of Lewis antigen
71
New cards
Murrant in 1946
Named after one of the first individuals to make the antibody reported by -name- in -year-

\
Answer: -name- in -year-
72
New cards
lymphocytes, platelets, tissues (pancreas, stomach, intestines, skeletal muscles, renal cortex, and adrenal gland)

\
found in the saliva as glycoproteins
The lewis system is found --
73
New cards
Le
Le^a has the __ gene
74
New cards
Le, Se, H
Le^b has the __ genes (3)
75
New cards
One of the problems are Lewis glycolipids are not detectable in the plasma until about
10 days after birth
76
New cards
Why was the Lewis blood ground undetectable until 10 days after birth ?
IgM, no placental transfer
77
New cards
Antibody class of Lutheran a?
Immediate Spin Phase
78
New cards
Antibody class of Lutheran b?
Antiglobulin Phase
79
New cards
Le (a-b-)
Lewis phenotype found in cord blood, cancer, and pregnant women
80
New cards
Le (a+b-)
Lewis phenotype present in non-secretors
81
New cards
Le (a-b+)
presentLewis phenotype in secretors
82
New cards
Lewis antibodies
* Naturally occurring \[Le(a-b-)\]
* Generally IgM, Immediate Spin Phase
* Neutralize by the plasma
83
New cards
Anti-Le^a
Most commonly encountered Lewis antibody
84
New cards
Anti-Le^bh
\-- reacts best when both the Leb and the H antigens are present
85
New cards
Anti-Le^bL
\-- recognizes any Leb antigen regardless of the ABO type
86
New cards
Le^b
associated with receptor H. pylori and Norwalk virus
87
New cards
Le^x
marker for Reedsternberg cell
88
New cards
Le(a-b-)
increase renal graft and heart disease
89
New cards
Le(a-b-)
increases susceptibility to infections by Candida and uropathogenic E.coli
90
New cards
P1PK, Globoside, Globoside collection
P blood group consists of --,--, and --
91
New cards
007
What are the first 3 digits of the lewis system?
92
New cards
003
What are the first 3 digits of the P1PK?
93
New cards
028
What are the first 3 digits of the Globoside (GLOB)?
94
New cards
209
What are the first 3 digits of the Globoside collection (LKE)?
95
New cards
7 years
The P1 Antigen is poorly expressed at birth and may take up --- to be fully expressed.
96
New cards
P1 and P2
In the P blood group, -- and -- are the most common
97
New cards
Landsteiner and Levine
Who introduced the P1 antigen?
98
New cards
P and P^k
antigens have been found in plasma as glycosphingolipid and glycoproteins in hydatid fluid
99
New cards
glycosphingolipid and glycoproteins in hydatid fluid
P and P^k antigens have been found in plasma as -- and -- in --
100
New cards
Echinococcus granulosus and Fascioliasis
Anti-P1 is associated with -- and -- ?