OTHER BLOOD GROUPS PART 1

Antigens are not synthesized by the RBCs and are made by tissue cells

Lewis (007)

In the Lewis system, expression of the Ag is influenced by the _ and _ gene

Hh and Sese

What phenotype of Lewis is commonly associated with gastritis

Le(a-b+)

What phenotype of Lewis blood group is cord blood and red cells from newborn infants

Le(a-b-)

This blood group is important in disputed parentage testing

MNSs (002)

MNSs blood group includes a group of mostly low frequency “satellite” antigens are considered interrelated and form the ___________

Miltenberger subsystem

Where does MNSs genes located?

Chromosome 4

M/N antigen reside on _____

glycophorin A

S/s antigen reside on _____

glycophorin B

M gene codes for ____ at position _ and ____ at position _

serine - 1 ; glycine - 5

N gene codes for ____ at position _ and ____ at position _

leucine - 1 ; glutamic acid - 5

_______ is a result of a single amino acid substitution on glycophorin B

S/s antigen

S has ____ meanwhile s has _____

methionine ; threonine

This blood group is biochemically related to ABO, I and Lewis

P (003)

All Ags of P blood group shares a common precursor substance, what is this substance called?

Ceramide dihexose AKA Lactosyl ceramide

This has been identified in hydatid cyst fluid extracts of Lumbricoides terrestris & Ascaris suum

P1 substance

This is an IgM and has never caused HDN but sometimes cause transfusion reaction

Anti-P1

This was observed in individuals affected with hydatid cyst

Strong anti-P1

Anti-P has specificity of what antibody found in _____?

Biphasic Donath-Landsteiner ; Paroxysmal Cold Hemoglobinuria

An antibody of the P blood group system that is associated with abortion in early pregnancy

Anti-PP1Pk

The gene responsible for I antigen synthesis is ____ located on ____.

IGnt ; chromosome 6p24

What blood group collection has antigens that are not restricted to RBCs but found on most cells and various body fluids?

I blood group collection (027)

What blood group is not a syste, but are classified as a blood group collection?

I blood group collection (027)

This antibody is seen in patient with Mycoplasma pneumoniae infection

Anti-I

This antibody is seen in serum of patients with alcoholic cirrhosis

Anti-i

This blood group are found on RBCs only and antigens are inactivated when treated with ZZAP

Kell (006)

True or False

Kell blood group are destroyed by routine blood bank enzyme but are not destroyed by a combination of trypsin and chymotrypsin.

False, not destroyed by blood bank enzymes but destroyed by combination of trypsin and chymotrypsin

What blood group antibodies are a result of immune stimulation via transfusion or pregnancy?

Anti-K

XK gene is located at ______ of the chromosome _______

Short arm ; X chromosome

Lack of Kx is the basis for what disease?

McLeod syndrome/phenotype

It is the simplest and most straightforward blood group system

Kidd (009)

In what chromosome does Kidd blood group system located?

Chromosome 18q11-q12

What antigen are found on platelets, lymphocytes, monocytes, or granulocytes?

Jk a and Jk b

This blood group system, is particularly notorious for its danger in causing severe and often fatal delayed hemolytic transfusion reaction.

Anti-Jka and Anti-Jkb

True or False

Anti-Jka and Anti-Jkb are known to cause HDN

True

This antibody was known to be found in a hemophiliac male who received multiple transfusion

Fya

This blood group was the first blood group antigen localized to a human autosome and was cloned.

Duffy (008)

Where does Fya and Fyb reside?

Duffy Antigen Receptor for Chemokine

Where is the Fy gene located?

Long arm of chromosome 1q22-q23

What Duffy phenotype are shown to be resistant to malarial infection?

Fy (a-b-)

What Duffy phenotype is known to be susceptible to malarial infection?

Fy (a+b+)