Lectin and Classical Pathways & Complement Pathway Evolution

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4 Terms

1
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What initiates the lectin and classical complement pathways?

MBL binds to mannose on pathogen surfaces, and C-reactive protein binds to phosphocholine on pathogens.

2
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How do MBL and C-reactive protein act in the complement system?

Both act as opsonins and initiate the classical C3 convertase formation via MASP-1/2 (MBL) and C1q (C-reactive protein).

3
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What is the classical C3 convertase formed from MBL and C-reactive protein?

C4bC2b is the classical C3 convertase formed from MBL or C-reactive protein binding to pathogens.

4
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What organisms have homologs of C3 and factor B?

Echinoderms and fruit flies have homologs of C3 and factor B, which are upregulated by bacterial infection to enhance phagocytosis.