Neutrophils

Neutrophil

most common leukocyte present in dogs and cats

What are Neutrophils classified as?

granulocytes and phagocytic

Job of Neutrophils

first responders to damaged tissue, initiators of inflammation, line of defense against invading microorganisms (bacteria)

How many lobes does a mature Neutrophil have?

3-5

Band Neutrophils

immature, hyposegmented shaped nucleus with rounded ends neutrophils

"Left Shift"

increase in # of band neutrophils in the blood

Segmented Neutrophils

mature neutrophils

Are Neutrophils classified as mature or immature when their segmentation is < 1/3 width of the nucleus?

mature

If you are NOT sure if mature or immature what do you do?

classify as mature

Where are Neutrophils made?

bone marrow

Where do Neutrophils develop from?

stem cells

Neutropoesis

creation of neutrophils from the stem cells in the bone marrow

Stages of Maturation
(My Parents Make Me Buy My House)

myeloblast > promyelocyte > myelocyte > metamyelocyte > band neutrophil > mature neutrophil > hypersegmented neutrophil

Myeloblast

granulocyte precursor

Degenerative Neutrophils

more BANDS than mature segs. = less immature

Regenerative Neutrophils

more MATURE SEGS than bands = more mature

"Left Shift" is commonly present in what?

acute inflammatory responses

What does the Degree of "Left Shift" tell you?

severity of the patient's disease

Neutrophil Normals: Canine

400 bands/ mcL

Neutrophil Normals: Felines

300 bands/ mcL

When is a Neutrophil considered Hypersegmented?

>7 segments