Cell Cycle Checkpoints

G2 Checkpoint

The ________: checks for cells size, protein reserves, and most importantly that all of the chromosomes have been replicated and that the replicated DNA isnt damaged.

anaphase

Because the separation of the sister chromatids during ________ is an irreversible step, the cycle will not proceed until the kinetochores of each pair of sister chromatids are firmly anchored to at least two spindle fibers arising from opposite poles of the cell.

checkpoint mechanisms

If the ________ detect problems with the DNA, the cell cycle is halted, and the cell attempts to either complete DNA replication or repair the damaged DNA.

Mistakes

________ in the duplication or distribution of the chromosomes lead to mutations that may be passed forward to every new cell produced from an abnormal cell.

M Checkpoint

The ________: determines whether all the sister chromatids are correctly attached to the spindle microtubules.

problematic condition

The cell can halt the cycle and attempt to remedy the ________, or the cell can advance into G0 and await further signals when conditions improve.

Cell cycle checkpoints

one of several points in the eukaryotic cell cycle at which the progression of a cell to the next stage in the cycle can be halted until conditions are favorable

The G1 checkpoint

checks for adequate reserves, cell size, and genomic DNA damage

The G2 Checkpoint

checks for cells size, protein reserves, and most importantly that all of the chromosomes have been replicated and that the replicated DNA isnt damaged

The M Checkpoint

determines whether all the sister chromatids are correctly attached to the spindle microtubules

Mistakes in the duplication or distribution of the chromosomes lead to

mutations that may be passed forward to every new cell produced from an abnormal cell

To prevent a compromised cell from continuing to divide, there are

internal control mechanisms that operate at three main cell cycle checkpoints

Because the separation of the sister chromatids during anaphase is an irreversible step,

the cycle will not proceed until the kinetochores of each pair of sister chromatids are firmly anchored to at least two spindle fibers arising from opposite poles of the cell