Pituitary Gland Set 10

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How many hormones does the pituitary gland produce?

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1

How many hormones does the pituitary gland produce?

8

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2

# of Anterior lobe hormones

6

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3

# of Posterior lobe hormones

2

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4

Where is the pituitary gland?

sella turcica

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5

What happens if the Optic Chiasm in the pituitary gland is compressed?

Pituitary gland adenoma

Field of vision defects

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6

What is Prolactin essential for?

Lactation

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7

What happens to the levels of Prolactin during pregnancy?

◦Increases during pregnancy

◦peak level at term

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8

Cause of Hyperprolactinemia

Increased prolactin secretion from the pituitary gland

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9

What’s the most common abnormality associated with pituitary adenomas?

Hyperprolactinemia

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10

How is prolactinomas associated with amenorrhea?

Amenorrhea is the loss of normal periods.

It is caused by the interference of prolactin on the normal fluctuation of LHRH

Higher prolactin = greater likelihood of amenorrhea

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11

Hyperprolactinemia affects which age group primarily?

Affects premenopausal women, does not affect post.

In premenopausal women the release of GnRH is inhibited.

Hypogonadism is an associated synonym

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12

If someone has Galacctorrhea can their prolactin levels be normal?

Yes

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13

Symptoms associated with hypogonadism?

Infertility, oligomenorrhea, amenorrhea

rare galactorrhea

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14

15 ng/mL

What kind of prolactin level is this?

High for women at a reproductive age

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15

100 ng/mL

What kind of prolactin level is this?

Typically associated with overt hypogonadism

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16

20- 50 ng/mL

Is someone has this prolactin level what does it mean?

Mildly increased result

Can cause infertility even if there is no abnormality of the menstrual cycle

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17

What other endocrine disorder can cause hyperprolactinemia?

Primary hypothyroidism

Increases TRH (thyroid releasing hormone) by the hypothalamus

TFH stimulates prolactin (and TSH) release.

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18

When would prolactin be measured?

Measure prolactin in all with fertility problems or galactorrhea

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19

Explain these prolactin lab results:

◦<20 ng/ml in females

◦<15 in males

◦100-300 at term, in pregnancy

Normal levels of prolactin

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20

What prolactin level is indicative of an adenoma?

100

300 is virtually diagnostic

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21

Why is prolactin important in pregnancy?

Without prolactin there will not be any milk production

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