Chapter 33: Irritant Poisons

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Cobra venoms

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50 Terms

1

Cobra venoms

________ are quite toxic and they are a major cause of human envenoming morbidity and mortality.

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2

Instantaneous death

________ due to shock due to fear of snakebite is observed more often than the actual toxicity of the venom.

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3

Antivenom

________ is expensive, always in short supply, and has a limited shelf life.

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4

Neurotoxic factor

________ can mimic strychnine poisoning.

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5

Hemolytic factors

________ can mimic viperine snakebite.

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6

Bullae

________ can be aspirated to dryness with a fine sterile needle.

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7

Calcium gluconate

________ given intravenously can reduce edema /rash.

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8

Atropine

________ may be given to reduce the pulmonary edema (do not use morphine)

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9

Snakes

________ like cobra can inject /emit venom by spitting.

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10

Vomitus

________ shows normal contents initially, but later turns bilious or contains altered blood.

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11

Adrenocorticotrophic hormone

________ (ACTH) 25 mg in 1000 ml normal saline given as an intravenous drip can help in prevention of severe allergic reactions.

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12

Scorpion

________ is a poisonous insect (Arthropod) with a crab like body with eight legs and a segmented tail having a bulbous expansion and a sting in the last segment which has a clear, colourless venom (toxalbumin) having two components, a hemolytic and a neurotoxic fractions.

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13

Centipedes

________ belong to Myriapoda (under class Arthropods) and are organic animal irritants.

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14

absolute contraindication

There is no ________ to antivenom in patients with life- threatening systemic envenomation.

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15

rapid immobilization

Venom may have several functions for the snake such as ________ and predigestion of prey.

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16

Tongue

________ is forked at the tip and serves as a sense organ and can be protruded out even when the mouth is closed through a gap in the upper jaw.

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17

Snake venoms

________ are usually clear and amber-colored fluid when fresh.

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18

Snakes

________ are ectothermic (cold- blooded) limbless vertebrates of the Class Reptilia.

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19

Antivenom

________ is not always necessary; many patients are bitten by nonvenomous snakes, and a large portion of those bitten by venomous snakes are not envenomated.

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20

Antivenoms

________ have a range of specific and paraspecific neutralizing activity and are useless for venoms outside that range.

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21

Irritant poison

mainly produce inflammation on the site of contact, especially in the gastrointestinal tract, respiratory tract, and skin

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22

Jacobsons organ

a cavity in the roof of the mouth with olfactory cells in which the snake inserts the tips of the forked tongue

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23

Colubridae

They rely instead on the trauma caused by other teeth to provide an entry track for their “venom”

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24

Elapidae

They have small to moderate-sized fangs at the front of the mouth, possibly the “true fangs”.

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25

Viperidae

All species have well-developed, longer fangs on hinged maxillae, allowing rotation (elevation) when biting, than in any other groups of venomous snakes.

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26

Hydrophiidae

These are sea snakes and are closely related to the cobras, with similar fang structure, but live most or all of their lives in an aquatic, usually marine environment.

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27

Atractaspidae

These are side fanged viper like snakes confined to Africa and the Middle East. They have unusual fang structure and venoms, which contain endothelin-like compounds called sarafotoxins, causing potent smooth muscle contraction.

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28

Neurotoxic Venom

Venom common is Elapidae Snakes.

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29

Hemotoxic Venom

Venom common in Viperidae snakes

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30

Myotoxic Venom

Venom common in hydrophidae or sea snakes.

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31

Phosphorus

It acts as a protoplasmic poison due to which normal metabolism is disturbed and cellular oxidation is severely affected

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32

Chlorine

It acts as a direct irritant of the mucous membrane of the respiratory tract by locally forming hydrochloric acid as it comes in contact with moisture.

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33

Bromine

  • It is a reddish-brown liquid, volatilizing to red fumes at room temperature and emitting an unpleasant odor.

  • It is more often n use as medicine and act as a sedative and cough elixir.

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34

Iodine

  • A volatile crystalline substance with purple glittering color, a characteristic odor, and an acrid taste. It gives violet fumes/vapors at room temperature.

  • It acts as an antiseptic. It is a powerful irritant and vesicant.

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35

Formaldehyde

  • A colorless gas with a pungent odor. Commercially it is available as formalin, which is a 40 percent aqueous solution of formaldehyde gas.

  • A disinfectant, antiseptic, deodorant, tissue fixative, and embalming agent.

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36

Arsenic

It is not poisonous as it is insoluble in water and cannot be absorbed from the gastrointestinal tract.

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37

Metallic Mercury

______ is a heavy, silvery liquid and is nonpoisonous. But it volatilises at room temperature and inhalation of vapors is toxic.

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38

Lead

_____ compounds can act by producing spasms of the capillaries and arterioles or by fixation of the poison in the tissues such as brain, bones, etc.

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39

Copper sulfate

_______ is a crystalline salt with blue color and has a metallic taste. In small dose of 0.5 gm it acts as an emetic, but in large doses it acts as an irritant poison. Poisoning is usually accidental or suicidal.

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40

Iron

Its early features of poisoning are due to the corrosive effects of iron, while later effects are largely due to the disruption of the cellular prAbrus Precatoriusocesses.

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41

Abrus Precatorius

It is a slender vine and climber, with compound leaves having 10-15 pairs of narrow leaves, small pinkish flowers with seedpods which split open when ripe exposing 4-6 seeds within.

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42

Ricinus Communis

It is a large shrub with greenish-red leaves. Fruits are borne in clusters and are soft-spined greenish/ brownish capsules with seeds.

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43

Croton Tiglium

It is an evergreen tree with smooth ash-colored bark. The leaves of the tree are ovate-lanceolate. Flowers are small, and oblong. Fruits are three lobed containing oval, dark brown seeds, with brownish black colour and longitudinal striations.

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44

Calotropis

It is a tall shrub with yellowish-white bark, and oblong thick leaves and purplish or white flowers.

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45

Semicarpus Anacardium

It is a small tree of East Indian origin. Its flower is dull/greenish yellow in colour. Fruit is black, heart- shaped with hard rind within which is a thick fleshy pericarp which yields brown oily resinous fluid.

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46

Capsicum Annum

It is a small herb bearing somewhat long, tapering fruits, which become red when ripe, and possess a pungent odor and taste.

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47

Eucalyptus Globus

It is a tall tree with smooth bark, long curved leaves, and large flowers. Eucalyptus oil obtained by steam distillation of the extract derived from the leaves.

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48

Azadirachta Indica

It is a tree. Seed grown in the tree yields a yellowish oil (margosa oil), which has a disagreeable odour and bitter taste.

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49

Colchicum Autumnale

Perennial herb (Category: Bulbs) Height: 15-30 cm, with basal, slender leaves; and long, tubular, 6-parted, flowers which are pink, violet/ lavender or white in colour.

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50

Ergot

It is the sclerotium (mycelium) of a fungus Claviceps purpura, which grows on many cereals like rye, barley, wheat, oat, etc. fungus gradually replaces the whole grain to a dark purple mass, which on drying yields ergot.

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