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65 million
primates originated roughly _______ million years ago
Encephalized
humans are the most ________ species
Glires (rodents and rabbits)
At their body size, primates have 2x larger brains than _______
fossil skulls
one can estimate brain size from ____________
Endocranial cavity
the cavity within the skull in which the brain is housed
1.5-2 million years ago
Absolute brain size increased roughly ______
150,000 years ago
brain increased again roughly _________ as HOMO sapiens emerged. (tripled as modern humans evolved from early hominids)
Growth spirt #1
early hominids, correlates (roughly) with the taming of fire
Growth Spirt #2
onset of homo sapiens. Intraspecific competition for resources and mates
Neocortex, brainstem
the proportional size of the _________ increases predictably as overall brain size INCREASES, while the ____________ proportionally SHRINKS. first one comprises 80% of brain mass
Frontal lobe, occipital lobe, temporal
3 neocortical lobes
prefrontal cortex
becomes disproportionately larger as neocortex increases.
comprises nearly 30% of the entire neocortex in humans
Response inhibition and working memory
the prefrontal cortex is involved in....
Isotropic fractionation
it involves homogenizing brain tissue and counting the number of nuclei in a cell suspension to obtain an estimate of the number of neurons
Neurons
__________ numbers increases predictably with brain weight
More
Large primates brains contain ________ neurons than equally large rodents brains
Cerebellum
the highest proportion of neurons is found in the ____________
Language
_______ is arguably our most distinctive attribute as a species
Broca's aphasia
an inability to articulate speech
Patient "Tan"
able to comprehend speech and could physically move lips and tongue, but could not speak any other word but "tan"
Broca's area
a cortical region in the frontal lobe of the human brain with functions linked to speech production. (lesion on the posterior portion of the left inferior prefrontal cortex)
Language comprehension
Damage to posterior portions of the superior temporal love impairs _______ _________ without impairing speech
network of cortical areas
Language is likely supported by a widespread.......
left hemisphere dominant
only the late stages of speech are......
Dorsal Stream
speech production
Ventral Stream
language comprehension
Parkinson's and schizophrenia
Men are more likely to be diagnosed with _____ and _____
Depression
Women are more likely to be diagnosed with different forms of ________
zebra finch
male ______ sing very complex song to attract females, the females do not sing
song system
the network of brain regions that help them learn and produce these songs.
Are much larger in males than in females
sexually dimorphic nucleus (SDN)
a cell group in the preoptic area of rodents that is significantly larger in males than in females. (in males involved in sexual behaviors such as ejaculation)
Anteroventral periventricular nucleus (AVPV)
a cell group in the preoptic area that is larger in females than in males. Helps trigger ovulation.
more numerous
Dopaminergic neurons in the substantia nigra are _______ _______ in females than in males
Substantia nigra (SNc)
projects mainly to the dorsal striatum and releases dopamine
testosterone may be slightly toxic to dopaminergic neurons, while estrogen is not
Why are men more likely to develop Parkinson's than women?
neocortical neurons
Men tend to be taller than women and have more ______ _______
cortical gray matter, corpus callosum
compared to men, women tend to have proportionately more _______ and a proportionately larger ________
Intraspecific difference
a difference existing within a species or between individuals of a single species
Visual ability
retina to lateral geniculate nucleus to primary visual cortex (V1)
grow
Human brains continue to ______ for several years after birth
___________ surface area triples between birth and young adulthood, primarily due to myelination
synapses and the expansion of dendritic trees
Neocortical gray matter also increases in volume, mainly due to the addition of more.....
Delayed maturation
expansion and maturation are delayed in the prefrontal, parietal, and lateral temporal lobes.
Maybe why teenagers are most likely to take risks than adults
Girls, Boys
Gray matter volume peaks in _____ at 8.5 years of age; in _____ this peak is reached two years later
age 50
Brain volume remains the same until about around.....
cerebral ventricles
decrease in brain volume coincides with an increase in the size of the......
0.5%
in healthy people between ages 60 and 90, many neocortical regions shrink by _____ per year
amygdala and hippocampus
most age-related differences, outside the neocortex, are in the......
white matter as well as some neurons and synapses
as aging brains shrink in volume, the lose substantial amounts of........
Alzhiemer's Disease
a neurodegenerative disease that is associated with progressive dementia and the loss of synapses (and eventually neurons) in diverse brain regions. Characterized by amyloid plaques and neurofibrillary tangles
Early Stage of Alzheimer's Disease
mild inability to form new episodic(long term) memories
Late Stage of Alzheimer's Disease
old memories are lost, mood wings become more severe, and thought become confused
synapses
plaques and tangles destroy_____ and eventually kill neurons
Hippocampus and entorhinal cortex
Cholinergic neurons of the basal forebrain and the noradrenergic neurons in the locus coeruleus
main regions vulnerable to Alzheimer's disease