Studied by 2 peopleCell Death
Natural process that plays a crucial role in development, tissue homeostasis, and immune responses
Apoptosis
Programmed cell death characterized by cell shrinkage, chromatin condensation, DNA fragmentation, and formation of apoptotic bodies
Necrosis
Type of cell death resulting from acute cellular injury or trauma, involving cell swelling, organelle damage, membrane rupture, and release of cellular contents
Extrinsic Pathway
Apoptosis pathway initiated by the binding of extracellular death ligands to death receptors on the cell surface
Intrinsic Pathway
Apoptosis pathway regulated by the balance of pro-apoptotic and anti-apoptotic members of the Bcl-2 protein family
Caspases
Family of proteases that play a central role in apoptosis execution
Morphological Changes
Distinct changes in apoptotic cells, including cell shrinkage, membrane blebbing, chromatin condensation, and fragmentation into apoptotic bodies
Anti-Apoptotic Mechanisms
Cellular mechanisms that inhibit apoptosis and promote cell survival, such as the action of anti-apoptotic proteins like Bcl-2 and Bcl-XL
Dysregulation of Apoptosis
Implicated in various diseases, including cancer, neurodegenerative disorders, autoimmune diseases, and developmental abnormalities
Therapeutic Applications
Strategies targeting apoptosis for cancer treatment or promoting cell survival in conditions like neurodegeneration
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