Chapter 25: Evaluation of the Strength of Forensic DNA Profiling Results

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Mendel’s first law

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17 Terms

1

Mendel’s first law

The principle of segregation of alleles. Each pair of alleles segregates from others in the formation of gametes.

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2

Mendel’s second law

The principle of independent assortment of alleles. The segregation of each pair of alleles is independent of the segregation of other pairs during the formation of gametes.

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3

meiosis

Gametes are formed during a process known as ________, in which cells with haploid chromosome numbers (23 in humans) are produced by the division of cells with diploid chromosome numbers (46 in humans).

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4

Linked Genes

Genes residing very closely together on the same chromosome are usually inherited together.

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5

probabilities

The Mendelian inheritances of genes can often be measured using _____.

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6

Probability

A ratio of the number of actual occurrences of an event to the number of possible occurrences.

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7

Allele Frequency

It can be calculated directly by counting the number of alleles of one type at a given locus and dividing it by the total number of alleles at that locus in a sampled population.

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8

Genotype Frequency

It can be calculated by dividing the number of individuals with one genotype by the total number of individuals in a sampled population. Each genotype at the locus can be calculated separately.

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9

Heterozygosity

The proportion of alleles, at a given locus, that are heterozygous.

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10

Hardy–Weinberg Principle

It allows predictions of genotype frequencies to be made based on allelic frequencies.

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11

Observed Genotype Frequencies

Are calculated by dividing the number of individuals with one genotype by the total number of individuals in the population sampled.

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12

Population Match Probability

The probability of having a matching genotype between two randomly chosen individuals.

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13

Likelihood Ratio

This method is an alternative for evaluating the strength of a match.

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14

Hypothesis 1

The evidence and suspect profiles originated from the same source.

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15

Hypothesis 2

The evidence and suspect profiles did not originate from the same source.

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16

haplotype

The term _____ was first used to describe very closely linked polymorphic loci.

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17

Linkage Disequilibrium

Where recombination is very rare, certain allelic combinations occur in populations much more frequently than would be expected.

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