Chapter 7: Control of Gene Expression

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31 Terms

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Gene control
The regulatory mechanisms that determine when, where, and to what extent genes are expressed or "turned on" in an organism.
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Transcription factors
Proteins that can activate or repress gene expression by binding to specific DNA sequences known as regulatory elements.
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Promoters
DNA sequences located near the start of a gene that provide binding sites for transcription factors and RNA polymerase, initiating transcription.
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Enhancers
Regulatory elements that can be located far away from the gene they control and interact with promoters through DNA looping, enhancing transcription.
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Silencers
Regulatory elements that repress gene expression by interacting with transcription factors or blocking the binding of activators.
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Epigenetic modifications
Chemical modifications to DNA or histone proteins that can influence the accessibility of DNA to transcription factors and the transcriptional machinery.
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DNA methylation
The addition of a methyl group to the DNA molecule, often resulting in gene silencing.
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Histone modifications
Chemical modifications to histone proteins that can alter the structure of chromatin and either promote or inhibit gene expression.
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Non-coding RNAs
RNA molecules that do not code for proteins but can regulate gene expression at the transcriptional or post-transcriptional level.
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Alternative splicing
A process that allows the production of multiple protein isoforms from a single gene by selectively including or excluding specific exons during mRNA processing.
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Post-translational modifications
Chemical modifications to proteins that can regulate their activity, localization, and stability.
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Cell differentiation
The process by which unspecialized cells become specialized and acquire distinct structures and functions.
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Transcription regulators
Proteins that control gene expression by switching genes on and off through binding to specific DNA sequences.
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Signaling pathways
Intracellular pathways that transmit signals from the cell membrane to the nucleus, modulating gene expression and directing cell fate decisions.
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Epigenetic modifications
Chemical modifications to DNA or histone proteins that contribute to the establishment and maintenance of cell identity.
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Non-coding RNAs
RNA molecules that regulate gene expression at the transcriptional and post-transcriptional levels.
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Cell-cell interactions
Communication between neighboring cells that contributes to the creation and maintenance of specialized cell types.
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Enhancer RNAs
eRNAs are noncoding RNAs transcribed from enhancer regions of the genome.
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Circular RNAs
circRNAs are covalently closed RNA molecules formed by back-splicing, where a downstream splice donor site joins with an upstream splice acceptor site.
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Small interfering RNAs
siRNAs are incorporated into the RNA-induced silencing complex (RISC) and guide RISC to complementary mRNA sequences.
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Piwi-interacting RNAs
piRNAs guide Piwi proteins to complementary sequences in TE transcripts, resulting in their degradation or transcriptional silencing.
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Long noncoding RNAs
lncRNAs exhibit diverse mechanisms of action, including regulation of transcription, chromatin remodeling, and modulation of RNA processing.
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MicroRNAs
They regulate gene expression by binding to complementary sequences in the 3' untranslated region (UTR) of target messenger RNAs (mRNAs).
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Riboswitches
Riboswitches are structural elements present within mRNA molecules that can modulate gene expression in response to specific ligands.
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RNA interference
RNAi is a post-transcriptional mechanism that regulates gene expression by using small RNA molecules.
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Alternative splicing
Different combinations of exons within a pre-mRNA can be spliced together, generating multiple mRNA isoforms from a single gene.
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RNA editing
The nucleotide sequence of mRNA can be modified by enzymatic processes, leading to changes in the coding sequence or regulatory regions.
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Polyadenylation
The addition of a poly(A) tail to the 3' end of mRNA stabilizes the molecule, affecting its stability and translation efficiency.
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mRNA capping
The addition of a 5' cap to mRNA protects it from degradation and facilitates translation initiation.
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Mitotic stability
Mitotic stability ensures the faithful transmission of cell memory to daughter cells during cell division.
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Chromatin remodeling
Chromatin remodeling complexes help reinforce cell memory by maintaining the accessibility and organization of chromatin.