[BIO 120.3] Group 5 - Herpes Virus

Latent, Lytic

What are two characteristics of Herpesviridae?

Latent

When a virus is present in the body but exists in a resting or quiescent state without producing more virus.

Lytic

Virus causes cell death

glycoprotein B, D, H; Latency Associated Transcripts (LATs); Immediate Early Genes (IE genes)

What are 5 virulence factors of herpes viruses?

HSV-1, HSV-2, Varicella-Zoster

What are 3 members of Herpesviridae?

Lips → Sensory Nerves → Nerve Ganglia

Describe how HSV-1 travels throughout the body

Site of mucocutaneous infection (lips, mouth)

Where does HSV-1 initially replicate?

Retrograde transport

The HSV-1 travels along the nerve by what kind of transport towards the trigeminal ganglia?

Trigeminal ganglia (DRG)

What ganglia is the HSV-1 located in during its latent state?

HSV-1

What herpes virus evades immunity by blocking CD1d molecules, inhibiting natural killer T-cell activation?

Blocks CD1d molecules, inhibiting natural killer T cell activation

How does HSV-1 evade immunity?

Immune cells and cytokines

What cells does HSV-1 target to suppress immune responses?

HSV-1

Herpes Virus: Cold sores

HSV-1

Herpes Virus: Gingivostomatitis

HSV-1

Herpes Virus: Herpetic Whitlow

HSV-1, HSV-2

Herpes Virus: Swollen Lymph Nodes

TRUE

T/F: HSV-1 is most acquired during childhood

FALSE

T/F: HSV-1 is most acquired during adulthood

Contaminated Saliva or Bodily Secretions

How is HSV-1 transmitted?

Bodily Secretions

How is HSV-2 transmitted?

Genital Mucosa

In what mucosa does initial replication of HSV-2 occur?

Lumbar sacral ganglia

What ganglia does the HSV-2 prefer?

Suppress viral replication, Prevent apoptosis

How does HSV-2 invade immune system?

Inhibit interferon activation

How does HSV-2 suppress immune system of host?

HSV-2

Herpes Virus: Genital Ulcers

HSV-2

Herpes Virus: Painful Urination

HSV-2

Herpes Virus: Genital pain and itching

HSV-2

Herpes Virus: urethral discharge

TRUE

T/F: HSV-1 is more prevalent than HSV-2

FALSE

T/F: HSV-2 is more prevalent than HSV-1

Respiratory droplets or bodily secretions

How is VZV transmitted?

Respiratory Mucosa

In what mucosa does initial replication of VZV occur?

Dorsal Root Ganglia

In what ganglia does VZV establish its latency?

Hiding in sensory ganglia, reducing immune surveillance

How does VZV invade immune system?

Inhibit interferon production, Modulating antigen presentation

How does VZV suppress immune system?

VZV

Herpes Virus: Congenital Varicella Syndrome

VZV

Herpes Virus: Chickenpox and Shingles

VZV

Herpes Virus: Post herpetic neuralgia

VZV

Herpes Virus: Ramsay Hunt Syndrome

TRUE

T/F: Both HSV-1 and and VZV are commonly acquired in childhood

FALSE

T/F: Among all 3 herpesviridae, it is only VZV that is commonly acquired in childhood

Acyclovir, Valacyclovir, Famiciclovir

What are 3 antiviral drugs against persistent Herpesviridae?

Varicella Vaccine (Varivax)

Vaccine for prevention against VZV?

Zoster Vaccine (Shingrix)

Vaccine that serves as guard against shingles?