Williams Drugs

Name an oral abortifacient and it’s PG receptor

Misoprostol: PGE1

Name an oral contraceptive and it’s PG receptor

Mifepristone; PGE1

Name an abortifacient suppository and it’s PG receptor

Dinoprostol; PGE2

Name an abortifacient injection and it’s PG receptor

Carboprost tromethamine; PGF2a

Name a drug used to treat erectile dysfunction and it’s PG receptor

Alprostadil; PGE1

Name a cytoprotection drug that can treat ulcers and it’s receptor

Misoprostol; PGE1

Name a drug (s) that can treat glaucoma and their receptor

Latanoprost (Xatalan)

Bimatoprost (Lumigan)

Travoprost

PGF2a

Name a drug(ss that can treat Pulmonary Arterial HTN ( or PAH) and their receptors

Epoprostenol

Iloprost

Treprostinil

PGI2

What are the symptoms to PAH treatment

Flushing, Jaw pain, headache , & Nausea

Name the drug to treat Ductus Arteriosus Maintenance and the PG receptor. What is the route of administration?

Alprostadil, PGE1, and the route of administration is intravenous.

Name the drug to treat Ductus Arteriosus Closure

Indomethacin

Failure to close Ductus Arteriosus leads to ______, ________ & ________

Pulmonary HTN, CHF & Arrhythmia

Drug thats used to replace morphine in some cases for post operative pain

Ketorolac

Dug that elevated transaminase
• Increased risk of fluid retention

Diflunisal

Drug that May impair the anti-platelet and anti-inflammatory effects of ASA

Ibuprofen

Drug that Twice the GI bleeding incidence as Ibuprofen
– Seems to be less likely to cause adverse cardiovascular side effects
– Contraindicated in hepatic disease

Naproxen

inhibits both COX and LOX

Ketoprofen

“ Cox-2” Selective drugs

Piroxicam

Oxaprozin

Etolodac

Celecoxib

Therapeutic applications for ASA’s anti-platelet function

prevent ischemia,
angina, infarction, thrombosis

COX1 is responsible for ________________

-COX2 specific drugs target _______________________

COX1 is responsible for normal processes;

inflamed tissue,
while sparing physiological COX-1 processesological COX-1 processes

Finish the pathway:

COX 1 —> ________——>TXA2——> Thrombus formation
and vasoconstriction ——>____________

Platelets; increase adverse CV effects

Finish the pathway:

COX 2 —> _________——>______——> Inhibit platelets and
and vasodilation

Endothelial cells ; PGI2

ASA P450 mediated oxidation

n acetyl-p- benzoquinone imine, NAPQ