Positive and Negative Selection of T Cells
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10 Terms
What is positive selection testing for?
Ability to recognise self-MHC
Which cells mediate positive selection?
Cortical epithelial cells
What happens if a TCR cannot bind self-MHC?
Apoptosis
What is negative selection testing for?
Excessive self-reactivity
Which cells mediate negative selection?
Dendritic cells and macrophages
What determines survival vs deletion?
Strength (affinity) of TCR-MHC binding
Why is selection described as a “paradox”?
Same self-MHC/self-peptide used for both survival and deletion
What is the final goal of thyme selection?
Low affinity self-reactive T cells
Why are low-affinity self-reactive T cells useful?
Can respond strongly to foreign peptides
What is clonal deletion?
Apoptosis of self-reactive lymphocytes
Note 
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