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General reaction
What is a nucleophile?
a “nucleus loving” molecule; donates an electron pair to form a bond.
List the common nucleophiles
Sn2 Mechanism. How many steps? Rate equation?
Single step with no intermediates. Bimolecular.
Describe the stereochemistry of SN2 Reactions
Inversion of configuration at the chiral center.
What substrates can undergo Sn2 Reactions?
methyl, primary, and secondary substrates.
How many steps are in a Sn2 reaction? What are they?
2 Steps. Step 1 - Fast protonation. Step 2 - Slow nucleophilic attack.
What is a nucleophilic attack?
The nucleophile approaches the substrate (typically an alkyl halide) from the opposite side of the leaving group.