Lectin Pathway of Complement Steps (Ch. 7)

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5 Terms

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What substances can activate the LECTIN pathway of complement

Carbohydrates on microbial cell walls

lectins, ficolins, CL-L1

Mannan-binding lectin (MBL)

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Lectin Pathway of Complement

Step 1

  1. MASP-2 binds to mannose (sugar) on bacterial cell wall…cleaves C4 & C2 to form C4bC2a (C3 convertase)

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Lectin Pathway of Complement

Step 2

  1. C3 convertase cleaves C3 to form C4bC2aC3b (C5 convertase)

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Lectin Pathway of Complement

Step 3

  1. C5 convertase cleaves C5…C5b inserts itself into cell membra

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Lectin Pathway of Complement

Step 4

  1. C5b attracts C6, C7, C8, & C9 to form the MAC