Pharm 19&20 P2 - Anxiety

Psychopharmacology

Drug treatment of psychiatric disorders

Anxiety disorders

exaggerated or inappropriate version of a natural response

Anxiety Disorders include

Panic disorder

OCD

General and Social Anxiety

Phobias

Psychological effects

feeling worried, nervousm agitated

Somatic and autonomic effects

tachycardia, sweating, sleep disorders, tense muscles

Is there an overlap of anxiety and depression

HUGE ONE

Anxiolytics

anxiety reducing drugs

What else is Benzodiazepine used for besides anxiety

Insomnia

Drugs that treat anxiety

• Benzodiazepines - MOST IMPORTANT

• Buspirone (5-HT1A) partial agonist,

• Beta-adrenoceptor antagonists

• SSRIs

What type of drug is Propranolol

Beta-Adrenoceptor antagonist

GABA

Gamma-AminoButyric Acid

What is GABA

an inhibatory neurotransmitter

Effects of Benzodiazepines

• - reduce anxiety (acute anxiety states)
  - sedation (decrease REM sleep)
  - reduce muscle tone and coordination
  - anticonvulsant (epilepsy – but contraindicated?)
  - anterograde amnesia (minor surgical procedures)

Unwanted effects if Ben.

Dependance

Withdrwls

respiratory depression

lots of sleep